eF-site ID 5bt4-B PDB Code 5bt4 Chain B click to enlarge Title Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe Classification TRANSCRIPTION Compound Bromodomain-containing protein 4 Source Homo sapiens (Human) (BRD4_HUMAN) Sequence B:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTE Description Functional site 1) chain B residue 81 type sequence W description binding site for residue 2LO B 201 source : AC3 2) chain B residue 84 type sequence Q description binding site for residue 2LO B 201 source : AC3 3) chain B residue 145 type sequence D description binding site for residue EDO B 202 source : AC4 4) chain B residue 82 type sequence P description binding site for residue 2LO C 201 source : AC5 5) chain B residue 83 type sequence F description binding site for residue 2LO C 201 source : AC5 6) chain B residue 92 type sequence L description binding site for residue 2LO C 201 source : AC5 7) chain B residue 140 type sequence N description binding site for residue 2LO C 201 source : AC5 8) chain B residue 146 type sequence I description binding site for residue 2LO C 201 source : AC5 9) chain B residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2

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