eF-site ID 5bt4-B
PDB Code 5bt4
Chain B

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Title Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe
Classification TRANSCRIPTION
Compound Bromodomain-containing protein 4
Source Homo sapiens (Human) (BRD4_HUMAN)
Sequence B:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW
PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN
AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTE
Description


Functional site

1) chain B
residue 81
type
sequence W
description binding site for residue 2LO B 201
source : AC3

2) chain B
residue 84
type
sequence Q
description binding site for residue 2LO B 201
source : AC3

3) chain B
residue 145
type
sequence D
description binding site for residue EDO B 202
source : AC4

4) chain B
residue 82
type
sequence P
description binding site for residue 2LO C 201
source : AC5

5) chain B
residue 83
type
sequence F
description binding site for residue 2LO C 201
source : AC5

6) chain B
residue 92
type
sequence L
description binding site for residue 2LO C 201
source : AC5

7) chain B
residue 140
type
sequence N
description binding site for residue 2LO C 201
source : AC5

8) chain B
residue 146
type
sequence I
description binding site for residue 2LO C 201
source : AC5

9) chain B
residue 140
type SITE
sequence N
description Acetylated histone binding => ECO:0000269|PubMed:22464331
source Swiss-Prot : SWS_FT_FI1

10) chain B
residue 99
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI2


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