eF-site ID 5bt4-ABC PDB Code 5bt4 Chain A, B, C click to enlarge Title Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe Classification TRANSCRIPTION Compound Bromodomain-containing protein 4 Source Homo sapiens (Human) (BRD4_HUMAN) Sequence A:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE B:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTE C:  NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPF QQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQ ECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE LPTE Description (1)  Bromodomain-containing protein 4 Functional site 1) chain A residue 81 type sequence W description binding site for residue 2LO A 201 source : AC1 2) chain A residue 82 type sequence P description binding site for residue 2LO A 201 source : AC1 3) chain A residue 92 type sequence L description binding site for residue 2LO A 201 source : AC1 4) chain A residue 94 type sequence L description binding site for residue 2LO A 201 source : AC1 5) chain A residue 140 type sequence N description binding site for residue 2LO A 201 source : AC1 6) chain C residue 121 type sequence N description binding site for residue 2LO A 201 source : AC1 7) chain C residue 124 type sequence E description binding site for residue 2LO A 201 source : AC1 8) chain C residue 127 type sequence Q description binding site for residue 2LO A 201 source : AC1 9) chain C residue 128 type sequence D description binding site for residue 2LO A 201 source : AC1 10) chain A residue 100 type sequence I description binding site for residue EDO A 202 source : AC2 11) chain A residue 101 type sequence I description binding site for residue EDO A 202 source : AC2 12) chain A residue 102 type sequence K description binding site for residue EDO A 202 source : AC2 13) chain A residue 103 type sequence T description binding site for residue EDO A 202 source : AC2 14) chain A residue 135 type sequence N description binding site for residue EDO A 202 source : AC2 15) chain B residue 81 type sequence W description binding site for residue 2LO B 201 source : AC3 16) chain B residue 84 type sequence Q description binding site for residue 2LO B 201 source : AC3 17) chain C residue 82 type sequence P description binding site for residue 2LO B 201 source : AC3 18) chain C residue 83 type sequence F description binding site for residue 2LO B 201 source : AC3 19) chain C residue 91 type sequence K description binding site for residue 2LO B 201 source : AC3 20) chain C residue 92 type sequence L description binding site for residue 2LO B 201 source : AC3 21) chain C residue 94 type sequence L description binding site for residue 2LO B 201 source : AC3 22) chain C residue 140 type sequence N description binding site for residue 2LO B 201 source : AC3 23) chain C residue 146 type sequence I description binding site for residue 2LO B 201 source : AC3 24) chain B residue 145 type sequence D description binding site for residue EDO B 202 source : AC4 25) chain C residue 76 type sequence K description binding site for residue EDO B 202 source : AC4 26) chain B residue 82 type sequence P description binding site for residue 2LO C 201 source : AC5 27) chain B residue 83 type sequence F description binding site for residue 2LO C 201 source : AC5 28) chain B residue 92 type sequence L description binding site for residue 2LO C 201 source : AC5 29) chain B residue 140 type sequence N description binding site for residue 2LO C 201 source : AC5 30) chain B residue 146 type sequence I description binding site for residue 2LO C 201 source : AC5 31) chain C residue 78 type sequence Q description binding site for residue 2LO C 201 source : AC5 32) chain C residue 81 type sequence W description binding site for residue 2LO C 201 source : AC5 33) chain C residue 82 type sequence P description binding site for residue 2LO C 201 source : AC5 34) chain C residue 84 type sequence Q description binding site for residue 2LO C 201 source : AC5 35) chain C residue 85 type sequence Q description binding site for residue 2LO C 201 source : AC5 36) chain C residue 149 type sequence M description binding site for residue 2LO C 201 source : AC5 37) chain A residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 39) chain C residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2 42) chain C residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 80-139 type prosite sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY WNAQECIQDFNTMFTNCYIY description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY source prosite : PS00633

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