eF-site ID 5bpk-ABCD PDB Code 5bpk Chain A, B, C, D click to enlarge Title Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases Classification HYDROLASE Compound Gamma-glutamyltranspeptidase (Ggt) Source Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (O25743_HELPY) Sequence A:  ASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAV AIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKA PLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAM LKKYGTKKLSQLIDPAIKLAENGYAISQRQAETLKEARER FLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTL GAKGFYQGQVAELIEKDMKKNGGIITKEDLASYNVKWRKP VVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGY GASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINK AYAKKIFDTIQPDTVTPSSQIKPGMGQL B:  ASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAV AIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKA PLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAM LKKYGTKKLSQLIDPAIKLAENGYAISQRQAETLKEARER FLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTL GAKGFYQGQVAELIEKDMKKNGGIITKEDLASYNVKWRKP VVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGY GASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINK AYAKKIFDTIQPDTVTPSSQIKPGMGQL C:  TTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNE MDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVL KNNKVFLVVGSPGGSRIITTVLQVISNVIDYNMNISEAVS APRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPV MGDVNAIQVLPKTKGSVFYGSTDPRKEF D:  TTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNE MDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVL KNNKVFLVVGSPGGSRIITTVLQVISNVIDYNMNISEAVS APRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPV MGDVNAIQVLPKTKGSVFYGSTDPRKEF Description Functional site 1) chain A residue 29 type sequence Y description binding site for residue EDO A 401 source : AC1 2) chain A residue 76 type sequence H description binding site for residue EDO A 402 source : AC2 3) chain C residue 565 type sequence K description binding site for residue EDO A 402 source : AC2 4) chain A residue 180 type sequence L description binding site for residue EDO A 403 source : AC3 5) chain A residue 184 type sequence R description binding site for residue EDO A 403 source : AC3 6) chain A residue 197 type sequence F description binding site for residue EDO A 403 source : AC3 7) chain A residue 198 type sequence F description binding site for residue EDO A 403 source : AC3 8) chain A residue 204 type sequence D description binding site for residue EDO A 403 source : AC3 9) chain A residue 205 type sequence Y description binding site for residue EDO A 403 source : AC3 10) chain A residue 28 type sequence S description binding site for residue EDO A 404 source : AC4 11) chain A residue 29 type sequence Y description binding site for residue EDO A 404 source : AC4 12) chain B residue 28 type sequence S description binding site for residue EDO A 404 source : AC4 13) chain B residue 29 type sequence Y description binding site for residue EDO A 404 source : AC4 14) chain C residue 499 type sequence S description binding site for residue EDO A 404 source : AC4 15) chain D residue 499 type sequence S description binding site for residue EDO A 404 source : AC4 16) chain A residue 341 type sequence D description binding site for residue EDO A 405 source : AC5 17) chain A residue 345 type sequence N description binding site for residue EDO A 405 source : AC5 18) chain A residue 272 type sequence R description binding site for residue EDO A 406 source : AC6 19) chain A residue 273 type sequence G description binding site for residue EDO A 406 source : AC6 20) chain A residue 274 type sequence Y description binding site for residue EDO A 406 source : AC6 21) chain C residue 460 type sequence K description binding site for residue EDO A 406 source : AC6 22) chain C residue 461 type sequence N description binding site for residue EDO A 406 source : AC6 23) chain A residue 297 type sequence E description binding site for residue EDO A 407 source : AC7 24) chain A residue 94 type sequence N description binding site for residue EDO A 408 source : AC8 25) chain A residue 188 type sequence L description binding site for residue EDO A 408 source : AC8 26) chain A residue 189 type sequence K description binding site for residue EDO A 408 source : AC8 27) chain A residue 191 type sequence S description binding site for residue EDO A 408 source : AC8 28) chain A residue 194 type sequence K description binding site for residue EDO A 408 source : AC8 29) chain A residue 145 type sequence A description binding site for residue EDO A 409 source : AC9 30) chain A residue 148 type sequence K description binding site for residue EDO A 409 source : AC9 31) chain A residue 149 type sequence K description binding site for residue EDO A 409 source : AC9 32) chain A residue 263 type sequence W description binding site for residue EDO A 409 source : AC9 33) chain A residue 260 type sequence N description binding site for residue EDO A 410 source : AD1 34) chain B residue 253 type sequence K description binding site for residue EDO A 410 source : AD1 35) chain B residue 257 type sequence A description binding site for residue EDO A 410 source : AD1 36) chain A residue 103 type sequence R description binding site for residue 4UD C 701 source : AD2 37) chain C residue 380 type sequence T description binding site for residue 4UD C 701 source : AD2 38) chain C residue 398 type sequence T description binding site for residue 4UD C 701 source : AD2 39) chain C residue 400 type sequence N description binding site for residue 4UD C 701 source : AD2 40) chain C residue 419 type sequence E description binding site for residue 4UD C 701 source : AD2 41) chain C residue 422 type sequence D description binding site for residue 4UD C 701 source : AD2 42) chain C residue 433 type sequence Y description binding site for residue 4UD C 701 source : AD2 43) chain C residue 451 type sequence S description binding site for residue 4UD C 701 source : AD2 44) chain C residue 452 type sequence S description binding site for residue 4UD C 701 source : AD2 45) chain C residue 453 type sequence M description binding site for residue 4UD C 701 source : AD2 46) chain C residue 472 type sequence G description binding site for residue 4UD C 701 source : AD2 47) chain C residue 473 type sequence G description binding site for residue 4UD C 701 source : AD2 48) chain C residue 476 type sequence I description binding site for residue 4UD C 701 source : AD2 49) chain A residue 91 type sequence H description binding site for residue EDO C 702 source : AD3 50) chain A residue 93 type sequence A description binding site for residue EDO C 702 source : AD3 51) chain C residue 390 type sequence G description binding site for residue EDO C 702 source : AD3 52) chain C residue 462 type sequence N description binding site for residue EDO C 702 source : AD3 53) chain C residue 463 type sequence K description binding site for residue EDO C 702 source : AD3 54) chain C residue 464 type sequence V description binding site for residue EDO C 702 source : AD3 55) chain A residue 326 type sequence R description binding site for residue EDO C 703 source : AD4 56) chain C residue 422 type sequence D description binding site for residue EDO C 703 source : AD4 57) chain C residue 423 type sequence F description binding site for residue EDO C 703 source : AD4 58) chain C residue 424 type sequence S description binding site for residue EDO C 703 source : AD4 59) chain C residue 429 type sequence N description binding site for residue EDO C 703 source : AD4 60) chain C residue 431 type sequence N description binding site for residue EDO C 703 source : AD4 61) chain C residue 435 type sequence L description binding site for residue EDO C 703 source : AD4 62) chain C residue 441 type sequence N description binding site for residue EDO C 703 source : AD4 63) chain C residue 501 type sequence P description binding site for residue EDO C 704 source : AD5 64) chain C residue 502 type sequence R description binding site for residue EDO C 704 source : AD5 65) chain C residue 503 type sequence F description binding site for residue EDO C 704 source : AD5 66) chain C residue 514 type sequence I description binding site for residue EDO C 704 source : AD5 67) chain C residue 515 type sequence E description binding site for residue EDO C 704 source : AD5 68) chain C residue 518 type sequence G description binding site for residue EDO C 704 source : AD5 69) chain A residue 30 type sequence P description binding site for residue EDO C 705 source : AD6 70) chain B residue 29 type sequence Y description binding site for residue EDO C 705 source : AD6 71) chain C residue 495 type sequence S description binding site for residue EDO C 705 source : AD6 72) chain C residue 560 type sequence S description binding site for residue EDO C 705 source : AD6 73) chain C residue 561 type sequence T description binding site for residue EDO C 705 source : AD6 74) chain A residue 93 type sequence A description binding site for residue EDO C 706 source : AD7 75) chain A residue 194 type sequence K description binding site for residue EDO C 706 source : AD7 76) chain A residue 202 type sequence H description binding site for residue EDO C 706 source : AD7 77) chain C residue 391 type sequence N description binding site for residue EDO C 706 source : AD7 78) chain C residue 387 type sequence D description binding site for residue EDO C 707 source : AD8 79) chain C residue 390 type sequence G description binding site for residue EDO C 707 source : AD8 80) chain C residue 555 type sequence S description binding site for residue EDO C 707 source : AD8 81) chain A residue 296 type sequence M description binding site for residue EDO C 708 source : AD9 82) chain A residue 311 type sequence N description binding site for residue EDO C 708 source : AD9 83) chain C residue 485 type sequence S description binding site for residue EDO C 708 source : AD9 84) chain C residue 490 type sequence Y description binding site for residue EDO C 708 source : AD9 85) chain C residue 516 type sequence K description binding site for residue EDO C 709 source : AE1 86) chain C residue 538 type sequence P description binding site for residue EDO C 709 source : AE1 87) chain C residue 539 type sequence V description binding site for residue EDO C 709 source : AE1 88) chain C residue 522 type sequence D description binding site for residue EDO C 710 source : AE2 89) chain C residue 525 type sequence D description binding site for residue EDO C 710 source : AE2 90) chain C residue 526 type sequence N description binding site for residue EDO C 710 source : AE2 91) chain D residue 526 type sequence N description binding site for residue EDO C 710 source : AE2 92) chain A residue 152 type sequence T description binding site for residue EDO C 711 source : AE3 93) chain A residue 201 type sequence G description binding site for residue EDO C 711 source : AE3 94) chain A residue 202 type sequence H description binding site for residue EDO C 711 source : AE3 95) chain C residue 389 type sequence W description binding site for residue EDO C 711 source : AE3 96) chain B residue 167 type sequence E description binding site for residue EDO B 401 source : AE4 97) chain B residue 214 type sequence K description binding site for residue EDO B 401 source : AE4 98) chain B residue 152 type sequence T description binding site for residue EDO B 402 source : AE5 99) chain B residue 201 type sequence G description binding site for residue EDO B 402 source : AE5 100) chain B residue 202 type sequence H description binding site for residue EDO B 402 source : AE5 101) chain D residue 389 type sequence W description binding site for residue EDO B 402 source : AE5 102) chain B residue 194 type sequence K description binding site for residue EDO B 403 source : AE6 103) chain B residue 202 type sequence H description binding site for residue EDO B 403 source : AE6 104) chain D residue 389 type sequence W description binding site for residue EDO B 403 source : AE6 105) chain D residue 391 type sequence N description binding site for residue EDO B 403 source : AE6 106) chain B residue 42 type sequence S description binding site for residue EDO B 405 source : AE7 107) chain B residue 43 type sequence S description binding site for residue EDO B 405 source : AE7 108) chain B residue 44 type sequence H description binding site for residue EDO B 405 source : AE7 109) chain B residue 45 type sequence P description binding site for residue EDO B 405 source : AE7 110) chain B residue 48 type sequence S description binding site for residue EDO B 405 source : AE7 111) chain D residue 565 type sequence K description binding site for residue EDO B 405 source : AE7 112) chain B residue 94 type sequence N description binding site for residue EDO B 406 source : AE8 113) chain B residue 188 type sequence L description binding site for residue EDO B 406 source : AE8 114) chain B residue 189 type sequence K description binding site for residue EDO B 406 source : AE8 115) chain B residue 191 type sequence S description binding site for residue EDO B 406 source : AE8 116) chain B residue 194 type sequence K description binding site for residue EDO B 406 source : AE8 117) chain B residue 199 type sequence K description binding site for residue EDO B 407 source : AE9 118) chain B residue 204 type sequence D description binding site for residue EDO B 407 source : AE9 119) chain B residue 206 type sequence Q description binding site for residue EDO B 407 source : AE9 120) chain B residue 353 type sequence F description binding site for residue EDO B 408 source : AF1 121) chain B residue 356 type sequence I description binding site for residue EDO B 408 source : AF1 122) chain B residue 357 type sequence Q description binding site for residue EDO B 408 source : AF1 123) chain B residue 358 type sequence P description binding site for residue EDO B 408 source : AF1 124) chain B residue 262 type sequence K description binding site for residue EDO B 409 source : AF2 125) chain B residue 334 type sequence D description binding site for residue EDO B 409 source : AF2 126) chain C residue 444 type sequence E description binding site for residue EDO B 409 source : AF2 127) chain B residue 109 type sequence K description binding site for residue EDO B 410 source : AF3 128) chain B residue 241 type sequence E description binding site for residue EDO B 410 source : AF3 129) chain B residue 245 type sequence K description binding site for residue EDO B 410 source : AF3 130) chain B residue 33 type sequence K description binding site for residue EDO B 411 source : AF4 131) chain B residue 34 type sequence N description binding site for residue EDO B 411 source : AF4 132) chain B residue 52 type sequence Q description binding site for residue EDO B 411 source : AF4 133) chain B residue 203 type sequence L description binding site for residue EDO B 412 source : AF5 134) chain B residue 204 type sequence D description binding site for residue EDO B 412 source : AF5 135) chain D residue 388 type sequence R description binding site for residue EDO B 412 source : AF5 136) chain B residue 180 type sequence L description binding site for residue EDO B 413 source : AF6 137) chain B residue 184 type sequence R description binding site for residue EDO B 413 source : AF6 138) chain B residue 197 type sequence F description binding site for residue EDO B 413 source : AF6 139) chain B residue 198 type sequence F description binding site for residue EDO B 413 source : AF6 140) chain B residue 204 type sequence D description binding site for residue EDO B 413 source : AF6 141) chain B residue 205 type sequence Y description binding site for residue EDO B 413 source : AF6 142) chain A residue 27 type sequence A description binding site for residue EDO D 702 source : AF7 143) chain B residue 27 type sequence A description binding site for residue EDO D 702 source : AF7 144) chain C residue 499 type sequence S description binding site for residue EDO D 702 source : AF7 145) chain D residue 499 type sequence S description binding site for residue EDO D 702 source : AF7 146) chain D residue 510 type sequence D description binding site for residue EDO D 703 source : AF8 147) chain D residue 511 type sequence E description binding site for residue EDO D 703 source : AF8 148) chain D residue 533 type sequence Q description binding site for residue EDO D 703 source : AF8 149) chain A residue 304 type sequence L description binding site for residue EDO D 704 source : AF9 150) chain D residue 521 type sequence A description binding site for residue EDO D 704 source : AF9 151) chain D residue 525 type sequence D description binding site for residue EDO D 704 source : AF9 152) chain D residue 501 type sequence P description binding site for residue EDO D 705 source : AG1 153) chain D residue 502 type sequence R description binding site for residue EDO D 705 source : AG1 154) chain D residue 503 type sequence F description binding site for residue EDO D 705 source : AG1 155) chain D residue 514 type sequence I description binding site for residue EDO D 705 source : AG1 156) chain D residue 515 type sequence E description binding site for residue EDO D 705 source : AG1 157) chain D residue 518 type sequence G description binding site for residue EDO D 705 source : AG1 158) chain A residue 29 type sequence Y description binding site for residue EDO D 706 source : AG2 159) chain B residue 30 type sequence P description binding site for residue EDO D 706 source : AG2 160) chain B residue 32 type sequence I description binding site for residue EDO D 706 source : AG2 161) chain D residue 495 type sequence S description binding site for residue EDO D 706 source : AG2 162) chain D residue 560 type sequence S description binding site for residue EDO D 706 source : AG2 163) chain D residue 561 type sequence T description binding site for residue EDO D 706 source : AG2 164) chain B residue 311 type sequence N description binding site for residue EDO D 707 source : AG3 165) chain D residue 485 type sequence S description binding site for residue EDO D 707 source : AG3 166) chain D residue 490 type sequence Y description binding site for residue EDO D 707 source : AG3 167) chain B residue 326 type sequence R description binding site for residue EDO D 708 source : AG4 168) chain D residue 422 type sequence D description binding site for residue EDO D 708 source : AG4 169) chain D residue 423 type sequence F description binding site for residue EDO D 708 source : AG4 170) chain D residue 429 type sequence N description binding site for residue EDO D 708 source : AG4 171) chain D residue 431 type sequence N description binding site for residue EDO D 708 source : AG4 172) chain D residue 435 type sequence L description binding site for residue EDO D 708 source : AG4 173) chain D residue 441 type sequence N description binding site for residue EDO D 708 source : AG4 174) chain D residue 387 type sequence D description binding site for residue EDO D 709 source : AG5 175) chain D residue 388 type sequence R description binding site for residue EDO D 709 source : AG5 176) chain D residue 389 type sequence W description binding site for residue EDO D 709 source : AG5 177) chain D residue 390 type sequence G description binding site for residue EDO D 709 source : AG5 178) chain D residue 555 type sequence S description binding site for residue EDO D 709 source : AG5 179) chain D residue 557 type sequence F description binding site for residue EDO D 709 source : AG5 180) chain C residue 526 type sequence N description binding site for residue EDO D 710 source : AG6 181) chain D residue 522 type sequence D description binding site for residue EDO D 710 source : AG6 182) chain D residue 525 type sequence D description binding site for residue EDO D 710 source : AG6 183) chain D residue 475 type sequence R description binding site for residue EDO D 711 source : AG7 184) chain D residue 513 type sequence R description binding site for residue EDO D 711 source : AG7 185) chain B residue 79 type sequence A description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 186) chain B residue 103 type sequence R description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 187) chain D residue 381 type sequence T description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 188) chain D residue 397 type sequence Y description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 189) chain D residue 398 type sequence T description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 190) chain D residue 400 type sequence N description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 191) chain D residue 419 type sequence E description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 192) chain D residue 422 type sequence D description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 193) chain D residue 433 type sequence Y description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 194) chain D residue 451 type sequence S description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 195) chain D residue 452 type sequence S description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 196) chain D residue 453 type sequence M description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 197) chain D residue 471 type sequence P description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 198) chain D residue 472 type sequence G description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 199) chain D residue 473 type sequence G description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 200) chain D residue 476 type sequence I description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG8 201) chain B residue 79 type sequence A description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 202) chain B residue 103 type sequence R description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 203) chain D residue 381 type sequence T description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 204) chain D residue 397 type sequence Y description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 205) chain D residue 398 type sequence T description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 206) chain D residue 400 type sequence N description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 207) chain D residue 419 type sequence E description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 208) chain D residue 422 type sequence D description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 209) chain D residue 433 type sequence Y description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 210) chain D residue 451 type sequence S description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 211) chain D residue 452 type sequence S description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 212) chain D residue 453 type sequence M description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 213) chain D residue 471 type sequence P description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 214) chain D residue 472 type sequence G description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 215) chain D residue 473 type sequence G description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 216) chain D residue 476 type sequence I description binding site for Di-peptide 4UD D 701 and THR D 380 source : AG9 217) chain C residue 380-404 type prosite sequence TTHYSVADRWGNAVSVTYTINASYG description G_GLU_TRANSPEPTIDASE Gamma-glutamyltranspeptidase signature. TTHySVadrwGNaVSvTyTINasYG source prosite : PS00462 218) chain A residue 82-109 type prosite sequence IGGGGFAVIHLANGENVALDFREKAPLK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGGGGFAVIHlAngenvaldfrek......APLK source prosite : PS00107

Display surface Download Links