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eF-site ID
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5bnj-B |
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PDB Code
|
5bnj |
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Chain
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B |
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click to enlarge
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Title
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CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one |
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Classification
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TRANSFERASE |
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Compound
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Cyclin-dependent kinase 8 |
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Source
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Homo sapiens (Human) (CCNC_HUMAN) |
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Sequence
|
B: |
KAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYW
KLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSL
KSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKT
RFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRP
LLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIA
LACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLY
EQWKNFDERKEMATILSKMPKPKPPP
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Description
|
(1) |
Cyclin-dependent kinase 8 (E.C.2.7.11.22,2.7.11.23), Cyclin-C
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Functional site
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1)
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chain |
B |
| residue |
144 |
| type |
|
| sequence |
E
|
| description |
binding site for residue FMT B 301
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| source |
: AC2
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|
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2)
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chain |
B |
| residue |
147 |
| type |
|
| sequence |
D
|
| description |
binding site for residue FMT B 302
|
| source |
: AC3
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