eF-site ID 5b25-C PDB Code 5b25 Chain C click to enlarge Title Crystal structure of human PDE1B with inhibitor 3 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B Source Homo sapiens (Human) (PDE1B_HUMAN) Sequence C:  TYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELL TRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHA ADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHT GTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDE MNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKT ALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKAL MEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFI VEPTFSVLTDVAEKSVQPLAGDPNPDVVSFRSTWVKRIQE NKQKWKERAASG Description Functional site 1) chain C residue 441 type sequence E description binding site for residue 4QJ A 603 source : AC3 2) chain C residue 474 type sequence P description binding site for residue 4QJ A 603 source : AC3 3) chain C residue 475 type sequence N description binding site for residue 4QJ A 603 source : AC3 4) chain C residue 478 type sequence V description binding site for residue 4QJ A 603 source : AC3 5) chain C residue 479 type sequence V description binding site for residue 4QJ A 603 source : AC3 6) chain C residue 351 type sequence Q description binding site for residue SO4 A 604 source : AC4 7) chain C residue 221 type sequence P description binding site for residue SO4 A 605 source : AC5 8) chain C residue 394 type sequence R description binding site for residue SO4 A 605 source : AC5 9) chain C residue 476 type sequence P description binding site for residue GOL A 607 source : AC7 10) chain C residue 227 type sequence H description binding site for residue ZN C 601 source : AD7 11) chain C residue 263 type sequence H description binding site for residue ZN C 601 source : AD7 12) chain C residue 264 type sequence D description binding site for residue ZN C 601 source : AD7 13) chain C residue 370 type sequence D description binding site for residue ZN C 601 source : AD7 14) chain C residue 264 type sequence D description binding site for residue MG C 602 source : AD8 15) chain C residue 222 type sequence Y description binding site for residue 4QJ C 603 source : AD9 16) chain C residue 371 type sequence I description binding site for residue 4QJ C 603 source : AD9 17) chain C residue 373 type sequence H description binding site for residue 4QJ C 603 source : AD9 18) chain C residue 388 type sequence L description binding site for residue 4QJ C 603 source : AD9 19) chain C residue 392 type sequence F description binding site for residue 4QJ C 603 source : AD9 20) chain C residue 409 type sequence L description binding site for residue 4QJ C 603 source : AD9 21) chain C residue 417 type sequence V description binding site for residue 4QJ C 603 source : AD9 22) chain C residue 420 type sequence S description binding site for residue 4QJ C 603 source : AD9 23) chain C residue 421 type sequence Q description binding site for residue 4QJ C 603 source : AD9 24) chain C residue 423 type sequence G description binding site for residue 4QJ C 603 source : AD9 25) chain C residue 424 type sequence F description binding site for residue 4QJ C 603 source : AD9 26) chain C residue 427 type sequence F description binding site for residue 4QJ C 603 source : AD9 27) chain C residue 196 type sequence R description binding site for residue SO4 C 604 source : AE1 28) chain C residue 249 type sequence S description binding site for residue SO4 C 604 source : AE1 29) chain C residue 250 type sequence E description binding site for residue SO4 C 604 source : AE1 30) chain C residue 316 type sequence T description binding site for residue SO4 C 605 source : AE2 31) chain C residue 317 type sequence K description binding site for residue SO4 C 605 source : AE2 32) chain C residue 344 type sequence K description binding site for residue SO4 C 606 source : AE3 33) chain C residue 347 type sequence K description binding site for residue SO4 C 606 source : AE3 34) chain C residue 271 type sequence T description binding site for residue GOL C 607 source : AE4 35) chain C residue 392 type sequence F description binding site for residue GOL C 607 source : AE4 36) chain C residue 407 type sequence S description binding site for residue GOL C 607 source : AE4 37) chain C residue 408 type sequence P description binding site for residue GOL C 607 source : AE4 38) chain C residue 410 type sequence C description binding site for residue GOL C 607 source : AE4 39) chain C residue 415 type sequence T description binding site for residue GOL C 608 source : AE5 40) chain C residue 417 type sequence V description binding site for residue GOL C 608 source : AE5 41) chain C residue 418 type sequence A description binding site for residue GOL C 608 source : AE5 42) chain C residue 419 type sequence Q description binding site for residue GOL C 608 source : AE5 43) chain C residue 223 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:O76083 source Swiss-Prot : SWS_FT_FI1 44) chain C residue 263 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 45) chain C residue 264 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 46) chain C residue 370 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 47) chain C residue 227 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 48) chain C residue 489 type MOD_RES sequence I description Phosphoserine => ECO:0000250|UniProtKB:Q01065 source Swiss-Prot : SWS_FT_FI3

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