eF-site ID 5b25-B PDB Code 5b25 Chain B click to enlarge Title Crystal structure of human PDE1B with inhibitor 3 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B Source Homo sapiens (Human) (PDE1B_HUMAN) Sequence B:  TYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELL TRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHA ADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHT GTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDE MNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKT ALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKAL MEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFI VEPTFSVLTDVAEKSVQPLAGDPNPDVVSFRSTWVKRIQE NKQKWKERAASG Description Functional site 1) chain B residue 198 type sequence K description binding site for residue GOL A 606 source : AC6 2) chain B residue 227 type sequence H description binding site for residue ZN B 601 source : AC8 3) chain B residue 263 type sequence H description binding site for residue ZN B 601 source : AC8 4) chain B residue 264 type sequence D description binding site for residue ZN B 601 source : AC8 5) chain B residue 370 type sequence D description binding site for residue ZN B 601 source : AC8 6) chain B residue 264 type sequence D description binding site for residue MG B 602 source : AC9 7) chain B residue 222 type sequence Y description binding site for residue 4QJ B 603 source : AD1 8) chain B residue 371 type sequence I description binding site for residue 4QJ B 603 source : AD1 9) chain B residue 373 type sequence H description binding site for residue 4QJ B 603 source : AD1 10) chain B residue 388 type sequence L description binding site for residue 4QJ B 603 source : AD1 11) chain B residue 392 type sequence F description binding site for residue 4QJ B 603 source : AD1 12) chain B residue 409 type sequence L description binding site for residue 4QJ B 603 source : AD1 13) chain B residue 417 type sequence V description binding site for residue 4QJ B 603 source : AD1 14) chain B residue 420 type sequence S description binding site for residue 4QJ B 603 source : AD1 15) chain B residue 421 type sequence Q description binding site for residue 4QJ B 603 source : AD1 16) chain B residue 423 type sequence G description binding site for residue 4QJ B 603 source : AD1 17) chain B residue 424 type sequence F description binding site for residue 4QJ B 603 source : AD1 18) chain B residue 427 type sequence F description binding site for residue 4QJ B 603 source : AD1 19) chain B residue 344 type sequence K description binding site for residue SO4 B 604 source : AD2 20) chain B residue 347 type sequence K description binding site for residue SO4 B 604 source : AD2 21) chain B residue 378 type sequence W description binding site for residue SO4 B 605 source : AD3 22) chain B residue 499 type sequence R description binding site for residue SO4 B 605 source : AD3 23) chain B residue 196 type sequence R description binding site for residue GOL B 606 source : AD4 24) chain B residue 314 type sequence N description binding site for residue GOL B 606 source : AD4 25) chain B residue 319 type sequence E description binding site for residue GOL B 606 source : AD4 26) chain B residue 271 type sequence T description binding site for residue GOL B 607 source : AD5 27) chain B residue 407 type sequence S description binding site for residue GOL B 607 source : AD5 28) chain B residue 408 type sequence P description binding site for residue GOL B 607 source : AD5 29) chain B residue 410 type sequence C description binding site for residue GOL B 607 source : AD5 30) chain B residue 278 type sequence T description binding site for residue GOL B 608 source : AD6 31) chain B residue 281 type sequence E description binding site for residue GOL B 608 source : AD6 32) chain B residue 441 type sequence E description binding site for residue 4QJ D 603 source : AE8 33) chain B residue 474 type sequence P description binding site for residue 4QJ D 603 source : AE8 34) chain B residue 475 type sequence N description binding site for residue 4QJ D 603 source : AE8 35) chain B residue 476 type sequence P description binding site for residue 4QJ D 603 source : AE8 36) chain B residue 478 type sequence V description binding site for residue 4QJ D 603 source : AE8 37) chain B residue 479 type sequence V description binding site for residue 4QJ D 603 source : AE8 38) chain B residue 316 type sequence T description binding site for residue SO4 D 604 source : AE9 39) chain B residue 318 type sequence D description binding site for residue SO4 D 604 source : AE9 40) chain B residue 351 type sequence Q description binding site for residue SO4 D 606 source : AF2 41) chain B residue 476 type sequence P description binding site for residue GOL D 607 source : AF3 42) chain B residue 223 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:O76083 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 227 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 44) chain B residue 263 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 45) chain B residue 264 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 46) chain B residue 370 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 47) chain B residue 489 type MOD_RES sequence I description Phosphoserine => ECO:0000250|UniProtKB:Q01065 source Swiss-Prot : SWS_FT_FI3

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