eF-site ID 5b25-A PDB Code 5b25 Chain A click to enlarge Title Crystal structure of human PDE1B with inhibitor 3 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B Source Homo sapiens (Human) (PDE1B_HUMAN) Sequence A:  TYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELL TRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHA ADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHT GTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDE MNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKT ALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKAL MEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFI VEPTFSVLTDVAEKSVQPLAGDPNPDVVSFRSTWVKRIQE NKQKWKERAASGITN Description Functional site 1) chain A residue 227 type sequence H description binding site for residue ZN A 601 source : AC1 2) chain A residue 263 type sequence H description binding site for residue ZN A 601 source : AC1 3) chain A residue 264 type sequence D description binding site for residue ZN A 601 source : AC1 4) chain A residue 370 type sequence D description binding site for residue ZN A 601 source : AC1 5) chain A residue 264 type sequence D description binding site for residue MG A 602 source : AC2 6) chain A residue 371 type sequence I description binding site for residue 4QJ A 603 source : AC3 7) chain A residue 373 type sequence H description binding site for residue 4QJ A 603 source : AC3 8) chain A residue 388 type sequence L description binding site for residue 4QJ A 603 source : AC3 9) chain A residue 392 type sequence F description binding site for residue 4QJ A 603 source : AC3 10) chain A residue 409 type sequence L description binding site for residue 4QJ A 603 source : AC3 11) chain A residue 417 type sequence V description binding site for residue 4QJ A 603 source : AC3 12) chain A residue 420 type sequence S description binding site for residue 4QJ A 603 source : AC3 13) chain A residue 421 type sequence Q description binding site for residue 4QJ A 603 source : AC3 14) chain A residue 423 type sequence G description binding site for residue 4QJ A 603 source : AC3 15) chain A residue 424 type sequence F description binding site for residue 4QJ A 603 source : AC3 16) chain A residue 427 type sequence F description binding site for residue 4QJ A 603 source : AC3 17) chain A residue 344 type sequence K description binding site for residue SO4 A 604 source : AC4 18) chain A residue 347 type sequence K description binding site for residue SO4 A 604 source : AC4 19) chain A residue 499 type sequence R description binding site for residue SO4 A 605 source : AC5 20) chain A residue 196 type sequence R description binding site for residue GOL A 606 source : AC6 21) chain A residue 198 type sequence K description binding site for residue GOL A 606 source : AC6 22) chain A residue 314 type sequence N description binding site for residue GOL A 606 source : AC6 23) chain A residue 319 type sequence E description binding site for residue GOL A 606 source : AC6 24) chain A residue 271 type sequence T description binding site for residue GOL A 607 source : AC7 25) chain A residue 395 type sequence Q description binding site for residue GOL A 607 source : AC7 26) chain A residue 407 type sequence S description binding site for residue GOL A 607 source : AC7 27) chain A residue 408 type sequence P description binding site for residue GOL A 607 source : AC7 28) chain A residue 410 type sequence C description binding site for residue GOL A 607 source : AC7 29) chain A residue 441 type sequence E description binding site for residue 4QJ B 603 source : AD1 30) chain A residue 474 type sequence P description binding site for residue 4QJ B 603 source : AD1 31) chain A residue 475 type sequence N description binding site for residue 4QJ B 603 source : AD1 32) chain A residue 476 type sequence P description binding site for residue 4QJ B 603 source : AD1 33) chain A residue 478 type sequence V description binding site for residue 4QJ B 603 source : AD1 34) chain A residue 479 type sequence V description binding site for residue 4QJ B 603 source : AD1 35) chain A residue 351 type sequence Q description binding site for residue SO4 B 604 source : AD2 36) chain A residue 198 type sequence K description binding site for residue GOL B 606 source : AD4 37) chain A residue 447 type sequence L description binding site for residue GOL B 607 source : AD5 38) chain A residue 476 type sequence P description binding site for residue GOL B 607 source : AD5 39) chain A residue 316 type sequence T description binding site for residue SO4 C 604 source : AE1 40) chain A residue 318 type sequence D description binding site for residue SO4 C 604 source : AE1 41) chain A residue 263-274 type prosite sequence HDYEHTGTTNSF description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDYeHtGttNsF source prosite : PS00126 42) chain A residue 223 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:O76083 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 227 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 44) chain A residue 263 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 45) chain A residue 264 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 46) chain A residue 370 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1TAZ, ECO:0007744|PDB:4NPV, ECO:0007744|PDB:4NPW source Swiss-Prot : SWS_FT_FI2 47) chain A residue 489 type MOD_RES sequence I description Phosphoserine => ECO:0000250|UniProtKB:Q01065 source Swiss-Prot : SWS_FT_FI3

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