eF-site ID 5awm-A PDB Code 5awm Chain A click to enlarge Title The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that of Mammalian JNK Proteins. Classification TRANSFERASE Compound Stress-activated protein kinase JNK Source (JNK_DROME) Sequence A:  QHYTVEVGDTNFTIHSRYINLRPIGGIVCAAYDTITQQNV AIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAF TPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLL YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL ARTAGTTFMMVVTRYYRAPEVILGMGYTENVDIWSVGCIM GEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT VRNYVENRPRYTGYSFDRLFPDGLFPNDQNSRRKASDARN LLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPE PYDHSVREHTVEQWKELIYEEVMDY Description Functional site 1) chain A residue 30 type sequence I description binding site for residue ANP A 401 source : AC1 2) chain A residue 31 type sequence G description binding site for residue ANP A 401 source : AC1 3) chain A residue 37 type sequence I description binding site for residue ANP A 401 source : AC1 4) chain A residue 38 type sequence V description binding site for residue ANP A 401 source : AC1 5) chain A residue 51 type sequence A description binding site for residue ANP A 401 source : AC1 6) chain A residue 53 type sequence K description binding site for residue ANP A 401 source : AC1 7) chain A residue 106 type sequence M description binding site for residue ANP A 401 source : AC1 8) chain A residue 107 type sequence E description binding site for residue ANP A 401 source : AC1 9) chain A residue 109 type sequence M description binding site for residue ANP A 401 source : AC1 10) chain A residue 112 type sequence N description binding site for residue ANP A 401 source : AC1 11) chain A residue 153 type sequence S description binding site for residue ANP A 401 source : AC1 12) chain A residue 154 type sequence N description binding site for residue ANP A 401 source : AC1 13) chain A residue 154 type sequence N description binding site for residue MG A 402 source : AC2 14) chain A residue 71 type sequence E description binding site for residue MG A 403 source : AC3 15) chain A residue 145-157 type prosite sequence IIHRDLKPSNIVV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV source prosite : PS00108 16) chain A residue 59-161 type prosite sequence FQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEE FQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKADC description MAPK MAP kinase signature. FqnvthakrayREfklmklvnhkniigllnaftpqrnleefqdvylvmelmdanlcqviqmdldhdrmsyllyqmlcgikhlhsagiih..........RDlKpsnivvkadC source prosite : PS01351 17) chain A residue 149 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 31 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 53 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links