eF-site ID 5ap2-A PDB Code 5ap2 Chain A click to enlarge Title Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Classification TRANSFERASE Compound DUAL SPECIFICITY PROTEIN KINASE TTK Source Homo sapiens (Human) (TTK_HUMAN) Sequence A:  QSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYV NLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITD QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV HTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDG TVNYMPPEAIKDMSPKSDVWSLGCILYYMTYGKTPFQQII NQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQ RISIPELLAHPYVQIQ Description Functional site 1) chain A residue 531 type sequence I description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 2) chain A residue 551 type sequence A description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 3) chain A residue 553 type sequence K description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 4) chain A residue 586 type sequence I description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 5) chain A residue 602 type sequence M description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 6) chain A residue 603 type sequence E description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 7) chain A residue 604 type sequence C description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 8) chain A residue 605 type sequence G description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 9) chain A residue 606 type sequence N description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 10) chain A residue 607 type sequence I description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 11) chain A residue 608 type sequence D description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 12) chain A residue 611 type sequence S description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 13) chain A residue 654 type sequence L description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 14) chain A residue 663 type sequence I description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 15) chain A residue 673 type sequence P description BINDING SITE FOR RESIDUE PWU A 1795 source : AC1 16) chain A residue 647 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 553 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 531 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 531-553 type prosite sequence IGSGGSSKVFQVLNEKKQIYAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGGSSKVFqVlnekkqi...........YAIK source prosite : PS00107 20) chain A residue 643-655 type prosite sequence IVHSDLKPANFLI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHsDLKpaNFLI source prosite : PS00108

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