eF-site ID 5al5-AB PDB Code 5al5 Chain A, B click to enlarge Title Crystal structure of TNKS2 in complex with 2-(4-((pyridin-4-yl)methyl) piperazin-1-yl)-3,4,5,6,7,8-hexahydroquinazolin-4-one Classification TRANSFERASE Compound TANKYRASE-2 Source Homo sapiens (Human) (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description Functional site 1) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 2) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 3) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 4) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 5) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 2162 source : AC2 6) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 2162 source : AC2 7) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 2162 source : AC2 8) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 2162 source : AC2 9) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 10) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 11) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 12) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 13) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 14) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 15) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 16) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 17) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 18) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 19) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 20) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 21) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 22) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 23) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 24) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 25) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 26) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 27) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE JL9 B 2165 source : AC7 28) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE JL9 B 2165 source : AC7 29) chain B residue 1049 type sequence A description BINDING SITE FOR RESIDUE JL9 B 2165 source : AC7 30) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE JL9 B 2165 source : AC7 31) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE JL9 B 2165 source : AC7 32) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE JL9 B 2165 source : AC7 33) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE JL9 B 2165 source : AC7 34) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 35) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 36) chain A residue 1033 type sequence S description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 37) chain A residue 1035 type sequence F description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 38) chain A residue 1049 type sequence A description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 39) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 40) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 41) chain A residue 1062 type sequence A description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 42) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 43) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 44) chain A residue 1075 type sequence I description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 45) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 46) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 47) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 48) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 49) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 50) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 51) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 52) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 53) chain A residue 1055 type sequence F description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 54) chain A residue 1111 type sequence S description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 55) chain A residue 1112 type sequence A description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 56) chain A residue 1127 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 57) chain A residue 1128 type sequence R description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 58) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 59) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 60) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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