eF-site ID 5al5-A PDB Code 5al5 Chain A click to enlarge Title Crystal structure of TNKS2 in complex with 2-(4-((pyridin-4-yl)methyl) piperazin-1-yl)-3,4,5,6,7,8-hexahydroquinazolin-4-one Classification TRANSFERASE Compound TANKYRASE-2 Source Homo sapiens (Human) (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE Description Functional site 1) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 2) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 3) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 4) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 5) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 6) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 7) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 8) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 9) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC3 10) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 11) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 12) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 13) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 14) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 15) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 16) chain A residue 1033 type sequence S description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 17) chain A residue 1035 type sequence F description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 18) chain A residue 1049 type sequence A description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 19) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 20) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 21) chain A residue 1062 type sequence A description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 22) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 23) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 24) chain A residue 1075 type sequence I description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 25) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE JL9 A 2165 source : AC8 26) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 27) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 28) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 29) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 30) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 31) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 32) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 33) chain A residue 1055 type sequence F description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 34) chain A residue 1111 type sequence S description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 35) chain A residue 1112 type sequence A description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 36) chain A residue 1127 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 37) chain A residue 1128 type sequence R description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 38) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 39) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 40) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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