eF-site ID 5al4-B PDB Code 5al4 Chain B click to enlarge Title Crystal structure of TNKS2 in complex with 2-(4-methylpiperazin-1-yl)- 3,4,5,6,7,8-hexahydroquinazolin-4-one Classification TRANSFERASE Compound TANKYRASE 2 Source Homo sapiens (Human) (TNKS2_HUMAN) Sequence B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description Functional site 1) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 2162 source : AC1 2) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 2162 source : AC1 3) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 2162 source : AC1 4) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 2162 source : AC1 5) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 6) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 7) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 8) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 9) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC4 10) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 11) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 12) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 13) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 14) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE GOL B 2165 source : AC7 15) chain B residue 978 type sequence E description BINDING SITE FOR RESIDUE GOL B 2165 source : AC7 16) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL B 2165 source : AC7 17) chain B residue 983 type sequence G description BINDING SITE FOR RESIDUE GOL B 2165 source : AC7 18) chain B residue 987 type sequence G description BINDING SITE FOR RESIDUE GOL B 2165 source : AC7 19) chain B residue 988 type sequence I description BINDING SITE FOR RESIDUE GOL B 2165 source : AC7 20) chain B residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL B 2165 source : AC7 21) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE WLH B 2166 source : AC9 22) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE WLH B 2166 source : AC9 23) chain B residue 1033 type sequence S description BINDING SITE FOR RESIDUE WLH B 2166 source : AC9 24) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE WLH B 2166 source : AC9 25) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE WLH B 2166 source : AC9 26) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE WLH B 2166 source : AC9 27) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE WLH B 2166 source : AC9 28) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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