eF-site ID 5al1-B PDB Code 5al1 Chain B click to enlarge Title Crystal structure of TNKS2 in complex with 2-(4-tert-butylphenyl)-1H, 2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one Classification TRANSFERASE Compound TANKYRASE 2 Source Homo sapiens (Human) (TNKS2_HUMAN) Sequence B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description Functional site 1) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 2) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 3) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 4) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 5) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 6) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC8 7) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC8 8) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC8 9) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC8 10) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC9 11) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 2164 source : AC9 12) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC9 13) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC9 14) chain B residue 978 type sequence E description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 15) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 16) chain B residue 982 type sequence G description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 17) chain B residue 983 type sequence G description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 18) chain B residue 988 type sequence I description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 19) chain B residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 20) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 21) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 22) chain B residue 1035 type sequence F description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 23) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 24) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 25) chain B residue 1061 type sequence F description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 26) chain B residue 1062 type sequence A description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 27) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 28) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 29) chain B residue 1075 type sequence I description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 30) chain B residue 1138 type sequence E description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 31) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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