eF-site ID 5al1-AB PDB Code 5al1 Chain A, B click to enlarge Title Crystal structure of TNKS2 in complex with 2-(4-tert-butylphenyl)-1H, 2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one Classification TRANSFERASE Compound TANKYRASE 2 Source Homo sapiens (Human) (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description Functional site 1) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 2) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 3) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 4) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 5) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 2162 source : AC1 6) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC2 7) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC2 8) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC2 9) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC2 10) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2164 source : AC3 11) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2164 source : AC3 12) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2164 source : AC3 13) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2164 source : AC3 14) chain A residue 1128 type sequence R description BINDING SITE FOR RESIDUE GOL A 2165 source : AC4 15) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2165 source : AC4 16) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2165 source : AC4 17) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2165 source : AC4 18) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2165 source : AC4 19) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 2165 source : AC4 20) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2165 source : AC4 21) chain A residue 978 type sequence E description BINDING SITE FOR RESIDUE GOL A 2166 source : AC5 22) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL A 2166 source : AC5 23) chain A residue 982 type sequence G description BINDING SITE FOR RESIDUE GOL A 2166 source : AC5 24) chain A residue 983 type sequence G description BINDING SITE FOR RESIDUE GOL A 2166 source : AC5 25) chain A residue 988 type sequence I description BINDING SITE FOR RESIDUE GOL A 2166 source : AC5 26) chain A residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL A 2166 source : AC5 27) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 28) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 29) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 30) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 31) chain A residue 1061 type sequence F description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 32) chain A residue 1062 type sequence A description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 33) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 34) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 35) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 36) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE GN5 A 2167 source : AC6 37) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 38) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 39) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 40) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 41) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 2162 source : AC7 42) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC8 43) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC8 44) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC8 45) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC8 46) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC9 47) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 2164 source : AC9 48) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC9 49) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 2164 source : AC9 50) chain B residue 978 type sequence E description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 51) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 52) chain B residue 982 type sequence G description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 53) chain B residue 983 type sequence G description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 54) chain B residue 988 type sequence I description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 55) chain B residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL B 2165 source : BC1 56) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 57) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 58) chain B residue 1035 type sequence F description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 59) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 60) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 61) chain B residue 1061 type sequence F description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 62) chain B residue 1062 type sequence A description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 63) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 64) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 65) chain B residue 1075 type sequence I description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 66) chain B residue 1138 type sequence E description BINDING SITE FOR RESIDUE GN5 B 2166 source : BC2 67) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 68) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 69) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 70) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 71) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 72) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 73) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 74) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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