eF-site ID 5aef-A PDB Code 5aef Chain A click to enlarge Title Electron cryo-microscopy of an Abeta(1-42)amyloid fibril Classification PROTEIN FIBRIL Compound AMYLOID BETA A4 PROTEIN Source (E9PG40_HUMAN) Sequence A:  QKLVFFAEDVGSNKGAIIGLMVGGVVIA Description (1)  AMYLOID BETA A4 PROTEIN Functional site 1) chain A residue 16 type SITE sequence K description Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 19 type SITE sequence F description Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 33 type SITE sequence G description Implicated in free radical propagation => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 4) chain A residue 35 type SITE sequence M description Susceptible to oxidation => ECO:0000269|PubMed:10535332 source Swiss-Prot : SWS_FT_FI4 5) chain A residue 40 type SITE sequence V description Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 source Swiss-Prot : SWS_FT_FI5 6) chain A residue 42 type SITE sequence A description Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430 source Swiss-Prot : SWS_FT_FI6

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