eF-site ID 5aaw-ABCDEFGHIJKL PDB Code 5aaw Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency Classification VIRAL PROTEIN Compound SCFV513 Source (5AAW) Sequence A:  QVQLVQSGAEVKKPGASVKVSCKAGFNIKDVYMSWVRQAP EQGLEWMGRIDPENGDTKYDPKLQGRVTMTADTSTNTAYM ELRSLRSDDTAVYYCARGWEGFAYWGQGTLVTVSSSDIVM TQSPASLAVSLGQRATISCRASENVDKYGNSFMHWYQQKP GQPPKLLIYRASELQWGVPDRFSGSGSGTDFTLTISSLQA EDVAVYYCQRSNEVPWTFGQGTKLEIKR B:  QQVQLVQSGAEVKKPGASVKVSCKAGFNIKDVYMSWVRQA PEQGLEWMGRIDPENGDTKYDPKLQGRVTMTADTSTNTAY MELRSLRSDDTAVYYCARGWEGFAYWGQGTLVTVSSSDIV MTQSPASLAVSLGQRATISCRASENVDKYGNSFMHWYQQK PGQPPKLLIYRASELQWGVPDRFSGSGSGTDFTLTISSLQ AEDVAVYYCQRSNEVPWTFGQGTKLEIKR C:  YTMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIE IRDVNKEKVVGRIISSTPLAENTNSVTNIELEPPFGDSYI VIGVGNSALTLHWFRK D:  QVQLVQSGAEVKKPGASVKVSCKAGFNIKDVYMSWVRQAP EQGLEWMGRIDPENGDTKYDPKLQGRVTMTADTSTNTAYM ELRSLRSDDTAVYYCARGWEGFAYWGQGTLVTVSSSDIVM TQSPASLAVSLGQRATISCRASENVDKYGNSFMHWYQQKP GQPPKLLIYRASELQWGVPDRFSGSGSGTDFTLTISSLQA EDVAVYYCQRSNEVPWTFGQGTKLEIKR E:  YTMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIE IRDVNKEKVVGRIISSTPLAENTNSVTNIELEPPFGDSYI VIGVGNSALTLHWFRK F:  QVQLVQSGAEVKKPGASVKVSCKAGFNIKDVYMSWVRQAP EQGLEWMGRIDPENGDTKYDPKLQGRVTMTADTSTNTAYM ELRSLRSDDTAVYYCARGWEGFAYWGQGTLVTVSSDIVMT QSPASLAVSLGQRATISCRASENVDKYGNSFMHWYQQKPG QPPKLLIYRASELQWGVPDRFSGSGSGTDFTLTISSLQAE DVAVYYCQRSNEVPWTFGQGTKLEIKR G:  YTMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIE IRDVNKEKVVGRIISSTPLAENTNSVTNIELEPPFGDSYI VIGVGNSALTLHW H:  QVQLVQSGAEVKKPGASVKVSCKAGFNIKDVYMSWVRQAP EQGLEWMGRIDPENGDTKYDPKLQGRVTMTADTSTNTAYM ELRSLRSDDTAVYYCARGWEGFAYWGQGTLVTVSSSDIVM TQSPASLAVSLGQRATISCRASENVDKYGNSFMHWYQQKP GQPPKLLIYRASELQWGVPDRFSGSGSGTDFTLTISSLQA EDVAVYYCQRSNEVPWTFGQGTKLEIKR I:  YTMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIE IRDVNKEKVVGRIISSTPLAENTNSVTNIELEPPFGDSYI VIGVGNSALTLHWFRK J:  YTMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIE IRDVNKEKVVGRIISSTPLAENTNSVTNIELEPPFGDSYI VIGVGNSALTLHWFRK K:  QVQLVQSGAEVKKPGASVKVSCKAGFNIKDVYMSWVRQAP EQGLEWMGRIDPENGDTKYDPKLQGRVTMTADTSTNTAYM ELRSLRSDDTAVYYCARGWEGFAYWGQGTLVTVSSSDIVM TQSPASLAVSLGQRATISCRASENVDKYGNSFMHWYQQKP GQPPKLLIYRASELQWGVPDRFSGSGSGTDFTLTISSLQA EDVAVYYCQRSNEVPWTFGQGTKLEIKR L:  YTMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIE IRDVNKEKVVGRIISSTPLAENTNSVTNIELEPPFGDSYI VIGVGNSALTLHWFRK Description

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