eF-site ID 5a80-AB PDB Code 5a80 Chain A, B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 40 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence A:  ESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAG LAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFT QYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWK NLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKE SGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMT LISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGF NCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRK FQPERYKLWKAGKDNTVIDHTLPTPEAAEFL B:  NPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVV PPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQ KKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFN PPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITI EGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSW YSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPL MLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAES TNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPER YKLWKAGKDNTVIDHTLPTPEAAEF Description Functional site 1) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1355 source : AC1 2) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1355 source : AC1 3) chain A residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1355 source : AC1 4) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1355 source : AC1 5) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 6) chain B residue 228 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 7) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 8) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 9) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE MN A 1356 source : AC3 10) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE MN A 1356 source : AC3 11) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE MN A 1356 source : AC3 12) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 13) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 14) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 15) chain A residue 132 type sequence Y description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 16) chain A residue 135 type sequence D description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 17) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 18) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 19) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 20) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 21) chain A residue 206 type sequence K description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 22) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 23) chain A residue 241 type sequence K description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 24) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE 9CJ A 1357 source : AC5 25) chain B residue 86 type sequence N description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 26) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 27) chain B residue 135 type sequence D description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 28) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 29) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 30) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 31) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 32) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 33) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 34) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 35) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE 9CJ B 1356 source : AC6 36) chain A residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN A 1358 source : AC7 37) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN A 1358 source : AC7 38) chain A residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN A 1358 source : AC7 39) chain A residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN A 1358 source : AC7 40) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 1357 source : AC8 41) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 1357 source : AC8 42) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 1357 source : AC8 43) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 1357 source : AC8 44) chain A residue 170 type sequence G description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 45) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 46) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 47) chain A residue 196 type sequence S description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 48) chain A residue 288 type sequence S description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 49) chain A residue 290 type sequence N description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 50) chain B residue 170 type sequence G description BINDING SITE FOR RESIDUE EDO B 1358 source : BC1 51) chain B residue 175 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1358 source : BC1 52) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1358 source : BC1 53) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE EDO B 1358 source : BC1 54) chain B residue 196 type sequence S description BINDING SITE FOR RESIDUE EDO B 1358 source : BC1 55) chain B residue 290 type sequence N description BINDING SITE FOR RESIDUE EDO B 1358 source : BC1 56) chain B residue 83 type sequence T description BINDING SITE FOR RESIDUE EDO B 1359 source : BC2 57) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE EDO B 1359 source : BC2 58) chain B residue 243 type sequence T description BINDING SITE FOR RESIDUE EDO B 1359 source : BC2 59) chain A residue 189 type sequence T description BINDING SITE FOR RESIDUE EDO A 1360 source : BC3 60) chain A residue 239 type sequence R description BINDING SITE FOR RESIDUE EDO A 1360 source : BC3 61) chain A residue 275 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1360 source : BC3 62) chain A residue 224 type sequence K description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 63) chain A residue 231 type sequence A description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 64) chain A residue 234 type sequence C description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 65) chain A residue 235 type sequence E description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 66) chain A residue 236 type sequence A description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 67) chain A residue 237 type sequence F description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 68) chain A residue 150 type sequence I description BINDING SITE FOR RESIDUE EDO A 1362 source : BC5 69) chain A residue 151 type sequence G description BINDING SITE FOR RESIDUE EDO A 1362 source : BC5 70) chain A residue 152 type sequence R description BINDING SITE FOR RESIDUE EDO A 1362 source : BC5 71) chain A residue 153 type sequence L description BINDING SITE FOR RESIDUE EDO A 1362 source : BC5 72) chain A residue 290 type sequence N description BINDING SITE FOR RESIDUE EDO A 1362 source : BC5 73) chain A residue 316 type sequence S description BINDING SITE FOR RESIDUE EDO A 1363 source : BC6 74) chain A residue 317 type sequence M description BINDING SITE FOR RESIDUE EDO A 1363 source : BC6 75) chain A residue 332 type sequence W description BINDING SITE FOR RESIDUE EDO A 1363 source : BC6 76) chain A residue 252 type sequence K description BINDING SITE FOR RESIDUE EDO B 1360 source : BC7 77) chain B residue 16 type sequence T description BINDING SITE FOR RESIDUE EDO B 1360 source : BC7 78) chain B residue 17 type sequence F description BINDING SITE FOR RESIDUE EDO B 1360 source : BC7 79) chain B residue 18 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1360 source : BC7 80) chain B residue 224 type sequence K description BINDING SITE FOR RESIDUE EDO B 1361 source : BC8 81) chain B residue 235 type sequence E description BINDING SITE FOR RESIDUE EDO B 1361 source : BC8 82) chain B residue 236 type sequence A description BINDING SITE FOR RESIDUE EDO B 1361 source : BC8 83) chain B residue 237 type sequence F description BINDING SITE FOR RESIDUE EDO B 1361 source : BC8 84) chain B residue 238 type sequence L description BINDING SITE FOR RESIDUE EDO B 1361 source : BC8 85) chain A residue 98 type sequence R description BINDING SITE FOR RESIDUE EDO B 1362 source : BC9 86) chain B residue 98 type sequence R description BINDING SITE FOR RESIDUE EDO B 1362 source : BC9 87) chain A residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 88) chain A residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 89) chain A residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 90) chain A residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 91) chain A residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 92) chain A residue 288 type catalytic sequence S description 370 source MCSA : MCSA1 93) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 94) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 95) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 96) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 97) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 98) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 99) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 100) chain A residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 101) chain A residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 102) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 103) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 104) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 105) chain A residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 106) chain A residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 107) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 108) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 109) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 110) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 111) chain A residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 112) chain A residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 113) chain A residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 114) chain A residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 115) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 116) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 117) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 118) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 119) chain A residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 120) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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