eF-site ID 5a7s-B PDB Code 5a7s Chain B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 44 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence B:  ESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAG LAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFT QYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWK NLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKE SGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMT LISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGF NCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRK FQPERYKLWKAGKDNTVIDHTLPTPEAAEFL Description Functional site 1) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC1 2) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE MN B 1355 source : AC1 3) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC1 4) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC3 5) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 1356 source : AC3 6) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC3 7) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC3 8) chain B residue 170 type sequence G description BINDING SITE FOR RESIDUE EDO B 1357 source : AC5 9) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1357 source : AC5 10) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE EDO B 1357 source : AC5 11) chain B residue 288 type sequence S description BINDING SITE FOR RESIDUE EDO B 1357 source : AC5 12) chain B residue 289 type sequence T description BINDING SITE FOR RESIDUE EDO B 1357 source : AC5 13) chain B residue 235 type sequence E description BINDING SITE FOR RESIDUE EDO B 1358 source : AC7 14) chain B residue 236 type sequence A description BINDING SITE FOR RESIDUE EDO B 1358 source : AC7 15) chain B residue 237 type sequence F description BINDING SITE FOR RESIDUE EDO B 1358 source : AC7 16) chain B residue 238 type sequence L description BINDING SITE FOR RESIDUE EDO B 1358 source : AC7 17) chain B residue 316 type sequence S description BINDING SITE FOR RESIDUE EDO B 1359 source : AC8 18) chain B residue 317 type sequence M description BINDING SITE FOR RESIDUE EDO B 1359 source : AC8 19) chain B residue 318 type sequence D description BINDING SITE FOR RESIDUE EDO B 1359 source : AC8 20) chain B residue 77 type sequence G description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 21) chain B residue 126 type sequence T description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 22) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE EDO B 1361 source : BC5 23) chain B residue 151 type sequence G description BINDING SITE FOR RESIDUE EDO B 1361 source : BC5 24) chain B residue 152 type sequence R description BINDING SITE FOR RESIDUE EDO B 1361 source : BC5 25) chain B residue 153 type sequence L description BINDING SITE FOR RESIDUE EDO B 1361 source : BC5 26) chain B residue 290 type sequence N description BINDING SITE FOR RESIDUE EDO B 1361 source : BC5 27) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE EDO B 1362 source : BC7 28) chain B residue 248 type sequence L description BINDING SITE FOR RESIDUE EDO B 1362 source : BC7 29) chain B residue 214 type sequence E description BINDING SITE FOR RESIDUE EDO B 1363 source : BC8 30) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE EDO B 1363 source : BC8 31) chain B residue 342 type sequence D description BINDING SITE FOR RESIDUE EDO B 1363 source : BC8 32) chain B residue 343 type sequence H description BINDING SITE FOR RESIDUE EDO B 1363 source : BC8 33) chain B residue 344 type sequence T description BINDING SITE FOR RESIDUE EDO B 1363 source : BC8 34) chain B residue 69 type sequence A description BINDING SITE FOR RESIDUE EDO B 1364 source : CC1 35) chain B residue 135 type sequence D description BINDING SITE FOR RESIDUE EDO B 1364 source : CC1 36) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 37) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 38) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 39) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 40) chain B residue 198 type sequence N description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 41) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 42) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 43) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 44) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE S2X B 1365 source : CC3 45) chain B residue 228 type sequence P description BINDING SITE FOR RESIDUE DMS B 1366 source : CC4 46) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE DMS B 1366 source : CC4 47) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE DMS B 1366 source : CC4 48) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 49) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 50) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 51) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 52) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 53) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 54) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 56) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 57) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 60) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 61) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 62) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 63) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 64) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

Display surface Download Links