eF-site ID 5a7s-A PDB Code 5a7s Chain A click to enlarge Title Crystal structure of human JMJD2A in complex with compound 44 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence A:  PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVP PKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQK KAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNP PIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIE GVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWY SVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLM LKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAEST NFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERY KLWKAGKDNTVIDHTLPTPEAAEFL Description Functional site 1) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE MN A 1355 source : AC2 2) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE MN A 1355 source : AC2 3) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE MN A 1355 source : AC2 4) chain A residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN A 1356 source : AC4 5) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN A 1356 source : AC4 6) chain A residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN A 1356 source : AC4 7) chain A residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN A 1356 source : AC4 8) chain A residue 170 type sequence G description BINDING SITE FOR RESIDUE EDO A 1357 source : AC6 9) chain A residue 175 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1357 source : AC6 10) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1357 source : AC6 11) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE EDO A 1357 source : AC6 12) chain A residue 288 type sequence S description BINDING SITE FOR RESIDUE EDO A 1357 source : AC6 13) chain A residue 290 type sequence N description BINDING SITE FOR RESIDUE EDO A 1357 source : AC6 14) chain A residue 154 type sequence R description BINDING SITE FOR RESIDUE EDO A 1358 source : AC9 15) chain A residue 155 type sequence T description BINDING SITE FOR RESIDUE EDO A 1358 source : AC9 16) chain A residue 157 type sequence L description BINDING SITE FOR RESIDUE EDO A 1358 source : AC9 17) chain A residue 158 type sequence D description BINDING SITE FOR RESIDUE EDO A 1358 source : AC9 18) chain A residue 289 type sequence T description BINDING SITE FOR RESIDUE EDO A 1358 source : AC9 19) chain A residue 290 type sequence N description BINDING SITE FOR RESIDUE EDO A 1358 source : AC9 20) chain A residue 291 type sequence F description BINDING SITE FOR RESIDUE EDO A 1358 source : AC9 21) chain A residue 314 type sequence K description BINDING SITE FOR RESIDUE EDO A 1359 source : BC1 22) chain A residue 316 type sequence S description BINDING SITE FOR RESIDUE EDO A 1359 source : BC1 23) chain A residue 317 type sequence M description BINDING SITE FOR RESIDUE EDO A 1359 source : BC1 24) chain A residue 332 type sequence W description BINDING SITE FOR RESIDUE EDO A 1359 source : BC1 25) chain A residue 224 type sequence K description BINDING SITE FOR RESIDUE EDO A 1360 source : BC2 26) chain A residue 235 type sequence E description BINDING SITE FOR RESIDUE EDO A 1360 source : BC2 27) chain A residue 236 type sequence A description BINDING SITE FOR RESIDUE EDO A 1360 source : BC2 28) chain A residue 237 type sequence F description BINDING SITE FOR RESIDUE EDO A 1360 source : BC2 29) chain A residue 238 type sequence L description BINDING SITE FOR RESIDUE EDO A 1360 source : BC2 30) chain A residue 77 type sequence G description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 31) chain A residue 126 type sequence T description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 32) chain A residue 83 type sequence T description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 33) chain A residue 230 type sequence S description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 34) chain A residue 243 type sequence T description BINDING SITE FOR RESIDUE EDO A 1361 source : BC4 35) chain A residue 217 type sequence K description BINDING SITE FOR RESIDUE EDO A 1362 source : BC6 36) chain A residue 302 type sequence Q description BINDING SITE FOR RESIDUE EDO A 1362 source : BC6 37) chain A residue 113 type sequence E description BINDING SITE FOR RESIDUE EDO B 1363 source : BC8 38) chain A residue 98 type sequence R description BINDING SITE FOR RESIDUE EDO A 1363 source : BC9 39) chain A residue 99 type sequence K description BINDING SITE FOR RESIDUE EDO A 1363 source : BC9 40) chain A residue 102 type sequence N description BINDING SITE FOR RESIDUE EDO A 1363 source : BC9 41) chain A residue 132 type sequence Y description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 42) chain A residue 135 type sequence D description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 43) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 44) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 45) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 46) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 47) chain A residue 198 type sequence N description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 48) chain A residue 206 type sequence K description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 49) chain A residue 208 type sequence W description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 50) chain A residue 241 type sequence K description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 51) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE S2X A 1364 source : CC2 52) chain A residue 105 type sequence K description BINDING SITE FOR RESIDUE DMS B 1366 source : CC4 53) chain A residue 226 type sequence F description BINDING SITE FOR RESIDUE DMS A 1365 source : CC5 54) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE DMS A 1365 source : CC5 55) chain A residue 228 type sequence P description BINDING SITE FOR RESIDUE DMS A 1365 source : CC5 56) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE DMS A 1365 source : CC5 57) chain A residue 230 type sequence S description BINDING SITE FOR RESIDUE DMS A 1365 source : CC5 58) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 59) chain A residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 60) chain A residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 61) chain A residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 62) chain A residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 63) chain A residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 64) chain A residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 66) chain A residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 67) chain A residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 70) chain A residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 71) chain A residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 72) chain A residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 73) chain A residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 74) chain A residue 288 type catalytic sequence S description 370 source MCSA : MCSA1

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