eF-site ID 5a7q-B PDB Code 5a7q Chain B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 30 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source null (KDM4A_HUMAN) Sequence B:  NPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVV PPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQ KKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFN PPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITI EGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSW YSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPL MLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAES TNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPER YKLWKAGKDNTVIDHTLPTPEAAEFL Description Functional site 1) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC2 2) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE MN B 1355 source : AC2 3) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC2 4) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE MN B 1356 source : AC4 5) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE MN B 1356 source : AC4 6) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 7) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 8) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 9) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 10) chain B residue 198 type sequence N description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 11) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 12) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 13) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 14) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 15) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 1358 source : AC7 16) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 1358 source : AC7 17) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 1358 source : AC7 18) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 1358 source : AC7 19) chain B residue 170 type sequence G description BINDING SITE FOR RESIDUE CL B 1359 source : BC2 20) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE CL B 1359 source : BC2 21) chain B residue 288 type sequence S description BINDING SITE FOR RESIDUE CL B 1359 source : BC2 22) chain B residue 18 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 23) chain B residue 263 type sequence E description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 24) chain B residue 266 type sequence E description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 25) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 26) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 32) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 33) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 34) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 35) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 36) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 37) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 38) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 39) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 40) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 41) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2

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