eF-site ID 5a7q-AB PDB Code 5a7q Chain A, B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 30 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence A:  SESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRA GLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLF TQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYW KNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEK ESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHF GEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKM TLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHG FNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVR KFQPERYKLWKAGKDNTVIDHTLPTPEAAEF B:  NPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVV PPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQ KKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFN PPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITI EGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSW YSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPL MLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAES TNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPER YKLWKAGKDNTVIDHTLPTPEAAEFL Description Functional site 1) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE MN A 1354 source : AC1 2) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE MN A 1354 source : AC1 3) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE MN A 1354 source : AC1 4) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC2 5) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE MN B 1355 source : AC2 6) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC2 7) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE MN A 1355 source : AC3 8) chain A residue 230 type sequence S description BINDING SITE FOR RESIDUE MN A 1355 source : AC3 9) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE MN B 1356 source : AC4 10) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE MN B 1356 source : AC4 11) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 12) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 13) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 14) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 15) chain B residue 198 type sequence N description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 16) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 17) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 18) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 19) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE KCH B 1357 source : AC5 20) chain A residue 132 type sequence Y description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 21) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 22) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 23) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 24) chain A residue 198 type sequence N description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 25) chain A residue 206 type sequence K description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 26) chain A residue 208 type sequence W description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 27) chain A residue 241 type sequence K description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 28) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 29) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 1358 source : AC7 30) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 1358 source : AC7 31) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 1358 source : AC7 32) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 1358 source : AC7 33) chain A residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN A 1357 source : AC8 34) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN A 1357 source : AC8 35) chain A residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN A 1357 source : AC8 36) chain A residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN A 1357 source : AC8 37) chain A residue 236 type sequence A description BINDING SITE FOR RESIDUE CL A 1358 source : AC9 38) chain A residue 237 type sequence F description BINDING SITE FOR RESIDUE CL A 1358 source : AC9 39) chain A residue 238 type sequence L description BINDING SITE FOR RESIDUE CL A 1358 source : AC9 40) chain A residue 170 type sequence G description BINDING SITE FOR RESIDUE CL A 1359 source : BC1 41) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE CL A 1359 source : BC1 42) chain A residue 288 type sequence S description BINDING SITE FOR RESIDUE CL A 1359 source : BC1 43) chain B residue 170 type sequence G description BINDING SITE FOR RESIDUE CL B 1359 source : BC2 44) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE CL B 1359 source : BC2 45) chain B residue 288 type sequence S description BINDING SITE FOR RESIDUE CL B 1359 source : BC2 46) chain B residue 18 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 47) chain B residue 263 type sequence E description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 48) chain B residue 266 type sequence E description BINDING SITE FOR RESIDUE EDO B 1360 source : BC3 49) chain A residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 50) chain A residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 51) chain A residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 52) chain A residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 53) chain A residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 54) chain A residue 288 type catalytic sequence S description 370 source MCSA : MCSA1 55) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 56) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 57) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 58) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 59) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 60) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 61) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 67) chain A residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 69) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 70) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 71) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 72) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 73) chain A residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 74) chain A residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 75) chain A residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 76) chain A residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 77) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 78) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 79) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 80) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 81) chain A residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 82) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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