eF-site ID 5a7q-A PDB Code 5a7q Chain A click to enlarge Title Crystal structure of human JMJD2A in complex with compound 30 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence A:  SESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRA GLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLF TQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYW KNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEK ESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHF GEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKM TLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHG FNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVR KFQPERYKLWKAGKDNTVIDHTLPTPEAAEF Description Functional site 1) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE MN A 1354 source : AC1 2) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE MN A 1354 source : AC1 3) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE MN A 1354 source : AC1 4) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE MN A 1355 source : AC3 5) chain A residue 230 type sequence S description BINDING SITE FOR RESIDUE MN A 1355 source : AC3 6) chain A residue 132 type sequence Y description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 7) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 8) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 9) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 10) chain A residue 198 type sequence N description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 11) chain A residue 206 type sequence K description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 12) chain A residue 208 type sequence W description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 13) chain A residue 241 type sequence K description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 14) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE KCH A 1356 source : AC6 15) chain A residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN A 1357 source : AC8 16) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN A 1357 source : AC8 17) chain A residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN A 1357 source : AC8 18) chain A residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN A 1357 source : AC8 19) chain A residue 236 type sequence A description BINDING SITE FOR RESIDUE CL A 1358 source : AC9 20) chain A residue 237 type sequence F description BINDING SITE FOR RESIDUE CL A 1358 source : AC9 21) chain A residue 238 type sequence L description BINDING SITE FOR RESIDUE CL A 1358 source : AC9 22) chain A residue 170 type sequence G description BINDING SITE FOR RESIDUE CL A 1359 source : BC1 23) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE CL A 1359 source : BC1 24) chain A residue 288 type sequence S description BINDING SITE FOR RESIDUE CL A 1359 source : BC1 25) chain A residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 26) chain A residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 27) chain A residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 28) chain A residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 29) chain A residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 30) chain A residue 288 type catalytic sequence S description 370 source MCSA : MCSA1 31) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 38) chain A residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 39) chain A residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 40) chain A residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 41) chain A residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5

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