eF-site ID 5a7p-B PDB Code 5a7p Chain B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 36 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence B:  LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKV VPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNI QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTF NPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGIT IEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKS WYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISP LMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAE STNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPE RYKLWKAGKDNTVIDHTLPTPEAAEF Description Functional site 1) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC1 2) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 3) chain B residue 228 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 4) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 5) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 6) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 7) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 8) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 9) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC6 10) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 1356 source : AC6 11) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC6 12) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC6 13) chain B residue 76 type sequence T description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 14) chain B residue 81 type sequence L description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 15) chain B residue 82 type sequence F description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 16) chain B residue 83 type sequence T description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 17) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 18) chain B residue 235 type sequence E description BINDING SITE FOR RESIDUE EDO B 1358 source : BC2 19) chain B residue 236 type sequence A description BINDING SITE FOR RESIDUE EDO B 1358 source : BC2 20) chain B residue 237 type sequence F description BINDING SITE FOR RESIDUE EDO B 1358 source : BC2 21) chain B residue 238 type sequence L description BINDING SITE FOR RESIDUE EDO B 1358 source : BC2 22) chain B residue 225 type sequence G description BINDING SITE FOR RESIDUE EDO B 1359 source : BC3 23) chain B residue 16 type sequence T description BINDING SITE FOR RESIDUE EDO A 1360 source : BC4 24) chain B residue 259 type sequence K description BINDING SITE FOR RESIDUE EDO A 1360 source : BC4 25) chain B residue 260 type sequence V description BINDING SITE FOR RESIDUE EDO A 1360 source : BC4 26) chain B residue 99 type sequence K description BINDING SITE FOR RESIDUE EDO B 1360 source : BC5 27) chain B residue 102 type sequence N description BINDING SITE FOR RESIDUE EDO B 1360 source : BC5 28) chain B residue 86 type sequence N description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 29) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 30) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 31) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 32) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 33) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 34) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 35) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 36) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 37) chain B residue 170 type sequence G description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 38) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 39) chain B residue 288 type sequence S description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 40) chain B residue 289 type sequence T description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 41) chain B residue 290 type sequence N description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 42) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 43) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 44) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 45) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 46) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 47) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 48) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 52) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 53) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 55) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 56) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 57) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 58) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4

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