eF-site ID 5a7p-AB PDB Code 5a7p Chain A, B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 36 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence A:  ESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAG LAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFT QYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWK NLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKE SGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFG EPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMT LISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGF NCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRK FQPERYKLWKAGKDNTVIDHTLPTPEAAEF B:  LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKV VPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNI QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTF NPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGIT IEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKS WYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISP LMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAE STNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPE RYKLWKAGKDNTVIDHTLPTPEAAEF Description Functional site 1) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC1 2) chain A residue 228 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC1 3) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC1 4) chain A residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC1 5) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC1 6) chain A residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 7) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 8) chain B residue 228 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 9) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 10) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1354 source : AC2 11) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE MN A 1355 source : AC3 12) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE MN A 1355 source : AC3 13) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE MN A 1355 source : AC3 14) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 15) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 16) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE MN B 1355 source : AC4 17) chain A residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN A 1356 source : AC5 18) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN A 1356 source : AC5 19) chain A residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN A 1356 source : AC5 20) chain A residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN A 1356 source : AC5 21) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC6 22) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 1356 source : AC6 23) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC6 24) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 1356 source : AC6 25) chain A residue 224 type sequence K description BINDING SITE FOR RESIDUE EDO A 1357 source : AC7 26) chain A residue 235 type sequence E description BINDING SITE FOR RESIDUE EDO A 1357 source : AC7 27) chain A residue 236 type sequence A description BINDING SITE FOR RESIDUE EDO A 1357 source : AC7 28) chain A residue 237 type sequence F description BINDING SITE FOR RESIDUE EDO A 1357 source : AC7 29) chain A residue 238 type sequence L description BINDING SITE FOR RESIDUE EDO A 1357 source : AC7 30) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE EDO A 1358 source : AC8 31) chain A residue 189 type sequence T description BINDING SITE FOR RESIDUE EDO A 1358 source : AC8 32) chain A residue 238 type sequence L description BINDING SITE FOR RESIDUE EDO A 1358 source : AC8 33) chain A residue 239 type sequence R description BINDING SITE FOR RESIDUE EDO A 1358 source : AC8 34) chain A residue 275 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1358 source : AC8 35) chain A residue 76 type sequence T description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 36) chain A residue 81 type sequence L description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 37) chain A residue 82 type sequence F description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 38) chain A residue 83 type sequence T description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 39) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE EDO A 1359 source : AC9 40) chain B residue 76 type sequence T description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 41) chain B residue 81 type sequence L description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 42) chain B residue 82 type sequence F description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 43) chain B residue 83 type sequence T description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 44) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE EDO B 1357 source : BC1 45) chain B residue 235 type sequence E description BINDING SITE FOR RESIDUE EDO B 1358 source : BC2 46) chain B residue 236 type sequence A description BINDING SITE FOR RESIDUE EDO B 1358 source : BC2 47) chain B residue 237 type sequence F description BINDING SITE FOR RESIDUE EDO B 1358 source : BC2 48) chain B residue 238 type sequence L description BINDING SITE FOR RESIDUE EDO B 1358 source : BC2 49) chain B residue 225 type sequence G description BINDING SITE FOR RESIDUE EDO B 1359 source : BC3 50) chain A residue 253 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1360 source : BC4 51) chain A residue 254 type sequence G description BINDING SITE FOR RESIDUE EDO A 1360 source : BC4 52) chain B residue 16 type sequence T description BINDING SITE FOR RESIDUE EDO A 1360 source : BC4 53) chain B residue 259 type sequence K description BINDING SITE FOR RESIDUE EDO A 1360 source : BC4 54) chain B residue 260 type sequence V description BINDING SITE FOR RESIDUE EDO A 1360 source : BC4 55) chain A residue 98 type sequence R description BINDING SITE FOR RESIDUE EDO B 1360 source : BC5 56) chain B residue 99 type sequence K description BINDING SITE FOR RESIDUE EDO B 1360 source : BC5 57) chain B residue 102 type sequence N description BINDING SITE FOR RESIDUE EDO B 1360 source : BC5 58) chain A residue 86 type sequence N description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 59) chain A residue 132 type sequence Y description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 60) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 61) chain A residue 188 type sequence H description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 62) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 63) chain A residue 206 type sequence K description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 64) chain A residue 208 type sequence W description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 65) chain A residue 241 type sequence K description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 66) chain A residue 276 type sequence H description BINDING SITE FOR RESIDUE 6Z1 A 1361 source : BC6 67) chain B residue 86 type sequence N description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 68) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 69) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 70) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 71) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 72) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 73) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 74) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 75) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE 6Z1 B 1361 source : BC7 76) chain A residue 170 type sequence G description BINDING SITE FOR RESIDUE DMS A 1362 source : BC8 77) chain A residue 177 type sequence Y description BINDING SITE FOR RESIDUE DMS A 1362 source : BC8 78) chain A residue 288 type sequence S description BINDING SITE FOR RESIDUE DMS A 1362 source : BC8 79) chain A residue 289 type sequence T description BINDING SITE FOR RESIDUE DMS A 1362 source : BC8 80) chain B residue 170 type sequence G description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 81) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 82) chain B residue 288 type sequence S description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 83) chain B residue 289 type sequence T description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 84) chain B residue 290 type sequence N description BINDING SITE FOR RESIDUE DMS B 1362 source : BC9 85) chain A residue 170 type catalytic sequence G description 370 source MCSA : MCSA1 86) chain A residue 177 type catalytic sequence Y description 370 source MCSA : MCSA1 87) chain A residue 188 type catalytic sequence H description 370 source MCSA : MCSA1 88) chain A residue 190 type catalytic sequence E description 370 source MCSA : MCSA1 89) chain A residue 276 type catalytic sequence H description 370 source MCSA : MCSA1 90) chain A residue 288 type catalytic sequence S description 370 source MCSA : MCSA1 91) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 92) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 93) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 94) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 95) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 96) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 97) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 98) chain A residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 99) chain A residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 100) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 101) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 102) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 103) chain A residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 104) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 105) chain A residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 106) chain A residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 107) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 108) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 109) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 110) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 111) chain A residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 112) chain A residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 113) chain A residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 114) chain A residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 115) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 116) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 117) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 118) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4

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