eF-site ID 5a7n-B PDB Code 5a7n Chain B click to enlarge Title Crystal structure of human JMJD2A in complex with compound 43 Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4A Source null (KDM4A_HUMAN) Sequence B:  LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKV VPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNI QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTF NPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGIT IEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKS WYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISP LMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAE STNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPE RYKLWKAGKDNTVIDHTLPTPEAAEF Description Functional site 1) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1360 source : AC8 2) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE MN B 501 source : BC1 3) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE MN B 501 source : BC1 4) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE MN B 501 source : BC1 5) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : BC2 6) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 502 source : BC2 7) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : BC2 8) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : BC2 9) chain B residue 170 type sequence G description BINDING SITE FOR RESIDUE EDO B 1354 source : BC3 10) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1354 source : BC3 11) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE EDO B 1354 source : BC3 12) chain B residue 288 type sequence S description BINDING SITE FOR RESIDUE EDO B 1354 source : BC3 13) chain B residue 290 type sequence N description BINDING SITE FOR RESIDUE EDO B 1354 source : BC3 14) chain B residue 109 type sequence P description BINDING SITE FOR RESIDUE EDO B 1355 source : BC4 15) chain B residue 124 type sequence N description BINDING SITE FOR RESIDUE EDO B 1355 source : BC4 16) chain B residue 128 type sequence N description BINDING SITE FOR RESIDUE EDO B 1355 source : BC4 17) chain B residue 181 type sequence W description BINDING SITE FOR RESIDUE EDO B 1355 source : BC4 18) chain B residue 182 type sequence K description BINDING SITE FOR RESIDUE EDO B 1355 source : BC4 19) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE SO4 B 1356 source : BC5 20) chain B residue 228 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1356 source : BC5 21) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1356 source : BC5 22) chain B residue 230 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1356 source : BC5 23) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 24) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 25) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 26) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 27) chain B residue 198 type sequence N description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 28) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 29) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 30) chain B residue 241 type sequence K description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 31) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE VAO B 4001 source : BC6 32) chain B residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 39) chain B residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 40) chain B residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 41) chain B residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 42) chain B residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 43) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 44) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 45) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 46) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 47) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 48) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2

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