eF-site ID 5a78-ABCD PDB Code 5a78 Chain A, B, C, D click to enlarge Title Crystal structure of the homing endonuclease I-CvuI in complex with I- CreI target (C1221) in the presence of 2 mM Mg revealing DNA not cleaved Classification HYDROLASE/DNA Compound DNA ENDONUCLEASE I-CVUI Source Chlorella vulgaris (Green alga) (5A78) Sequence A:  NFHDQLKFAWLAGFVDADGCINAQIVSREDYLLKYQVRVS LTVFQSTTQHFILLDIQKILGCGTVRKRNDGMSEFCVVGG TSLQTTLEKLLPYLQLKRAQAKLVLQIIKKLPNTKDPSVL MEAALLADKVGLLTDGKKRTILAENVRECLKKLGHVV B:  NFHDQLKFAWLAGFVDADGCINAQIVSREDYLLKYQVRVS LTVFQSTTQHFILLDIQKILGCGTVRKRNDGMSEFCVVGG TSLQTTLEKLLPYLQLKRAQAKLVLQIIKKLPNTKDPSVL MEAALLADKVGLLTDGKKRTILAENVRECLKKLGHVVS C:  TCAAAACGTCGTACGACGTTTTGA D:  TCAAAACGTCGTACGACGTTTTGA Description Functional site 1) chain A residue 22 type sequence A description BINDING SITE FOR RESIDUE MG D 1625 source : AC1 2) chain A residue 23 type sequence D description BINDING SITE FOR RESIDUE MG D 1625 source : AC1 3) chain B residue 23 type sequence D description BINDING SITE FOR RESIDUE MG D 1625 source : AC1 4) chain C residue 515 type sequence G description BINDING SITE FOR RESIDUE MG D 1625 source : AC1 5) chain D residue 614 type sequence C description BINDING SITE FOR RESIDUE MG D 1625 source : AC1 6) chain A residue 23 type sequence D description BINDING SITE FOR RESIDUE MG B 1164 source : AC2 7) chain B residue 22 type sequence A description BINDING SITE FOR RESIDUE MG B 1164 source : AC2 8) chain C residue 514 type sequence C description BINDING SITE FOR RESIDUE MG B 1164 source : AC2 9) chain D residue 615 type sequence G description BINDING SITE FOR RESIDUE MG B 1164 source : AC2

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