eF-site ID 5a6u-ABG
PDB Code 5a6u
Chain A, B, G

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Title Native mammalian ribosome-bound Sec61 protein-conducting channel in the 'non-inserting' state
Classification TRANSLATION
Compound SEC61A
Source ORGANISM_COMMON: DOG; ORGANISM_SCIENTIFIC: CANIS LUPUS FAMILIARIS;
Sequence A:  IQFKEKVLWTAITLFIFLVCCQSADPFYWMRVILASNRGT
LMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGA
QKLFGMIITIGQSIVYVMTCLLITIQLFVAGLIVLLLDEL
LQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGME
FEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIAT
IFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSN
IPIILQSALVSNLYVISQMLSARFSPVGGLCHYLSPPESF
GSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVA
KQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGAL
SVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSE
B:  EDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
G:  FVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAI
MGFIGFFVKLIHIPINNIIVGG
Description (1)  SEC61A, SEC61B, SEC61G


Functional site

1) chain G
residue 18
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P60059
source Swiss-Prot : SWS_FT_FI3

2) chain A
residue 168-177
type MOD_RES
sequence LLQKGYGLGS
description Phosphoserine => ECO:0000250|UniProtKB:P60059
source Swiss-Prot : SWS_FT_FI3

3) chain A
residue 260-285
type MOD_RES
sequence GFRVDLPIKSARYRGQYNTYPIKLFY
description Phosphoserine => ECO:0000250|UniProtKB:P60059
source Swiss-Prot : SWS_FT_FI3

4) chain A
residue 380-420
type MOD_RES
sequence IEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPT
A
description Phosphoserine => ECO:0000250|UniProtKB:P60059
source Swiss-Prot : SWS_FT_FI3

5) chain G
residue 36-61
type TRANSMEM
sequence IAMATAIGFAIMGFIGFFVKLIHIPI
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 444-458
type TRANSMEM
sequence GTGILLAVTIIYQYF
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 81-97
type TRANSMEM
sequence ISPIVTSGLIMQLLAGA
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

8) chain A
residue 110-131
type TRANSMEM
sequence ALFNGAQKLFGMIITIGQSIVY
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

9) chain A
residue 149-167
type TRANSMEM
sequence LLITIQLFVAGLIVLLLDE
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

10) chain A
residue 178-196
type TRANSMEM
sequence GISLFIATNICETIVWKAF
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 242-259
type TRANSMEM
sequence LMNLIATIFVFAVVIYFQ
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

12) chain A
residue 286-306
type TRANSMEM
sequence TSNIPIILQSALVSNLYVISQ
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

13) chain A
residue 357-379
type TRANSMEM
sequence DPVHAVVYIVFMLGSCAFFSKTW
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 421-437
type TRANSMEM
sequence AAFGGLCIGALSVLADF
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

15) chain G
residue 62-68
type TOPO_DOM
sequence NNIIVGG
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 132-148
type TOPO_DOM
sequence VMTC
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 197-241
type TOPO_DOM
sequence SPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYR
QNLPN
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 307-356
type TOPO_DOM
sequence MLSARFSPVGGLCHYLSPPESFGSVLE
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 438-443
type TOPO_DOM
sequence LGAIGS
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

20) chain G
residue 14-42
type prosite
sequence FVKDSIRLVKRCTKPDRKEFQKIAMATAI
description SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI
source prosite : PS01067

21) chain A
residue 75-94
type prosite
sequence TLMELGISPIVTSGLIMQLL
description SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL
source prosite : PS00755

22) chain A
residue 164-182
type prosite
sequence LLDELLQKGYGLGSGISLF
description SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF
source prosite : PS00756


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