eF-site ID 5a63-C PDB Code 5a63 Chain C click to enlarge Title Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. Classification HYDROLASE Compound Nicastrin Source (PEN2_HUMAN) Sequence C:  GAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFF WLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVL LQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVS GLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSA FLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTS GLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQR SLL Description (1)  NICASTRIN, PRESENILIN-1 (E.C.3.4.23.-), GAMMA-SECRETASE SUBUNIT APH-1A, GAMMA-SECRETASE SUBUNIT PEN-2 Functional site 1) chain C residue 140-158 type TOPO_DOM sequence DALGPGVVGIHGDSPYYFL description Cytoplasmic => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI1 2) chain C residue 208-213 type TOPO_DOM sequence PWYEAS description Cytoplasmic => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 90-118 type TRANSMEM sequence YYKLLKKADEGLASLSEDGRSPISIRQMA description Helical => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI3 4) chain C residue 180-186 type TRANSMEM sequence DACERRR description Helical => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI3 5) chain C residue 69-89 type TRANSMEM sequence YGLLIFGAAVSVLLQEVFRFA description Helical; Name=3 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI5 6) chain C residue 119-139 type TRANSMEM sequence YVSGLSFGIISGVFSVINILA description Helical; Name=4 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI6 7) chain C residue 159-179 type TRANSMEM sequence TSAFLTAAIILLHTFWGVVFF description Helical; Name=5 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI7 8) chain C residue 187-207 type TRANSMEM sequence YWALGLVVGSHLLTSGLTFLN description Helical; Name=6 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI8 9) chain C residue 214-234 type TRANSMEM sequence LLPIYAVTVSMGLWAFITAGG description Helical; Name=7 => ECO:0000269|PubMed:26280335 source Swiss-Prot : SWS_FT_FI9

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