eF-site ID 5a3c-A PDB Code 5a3c Chain A click to enlarge Title Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with NAD Classification TRANSFERASE Compound SIR2 FAMILY PROTEIN Source Streptococcus pyogenes serotype M2 (strain MGAS10270) (Q1JGN6_STRPD) Sequence A:  NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIG PRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRF VALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVA GYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAE QKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHA QKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRV SENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISAT KTIYQK Description (1)  SIR2 FAMILY PROTEIN (E.C.2.4.2.30) Functional site 1) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 2) chain A residue 149 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 3) chain A residue 180 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 4) chain A residue 183 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 5) chain A residue 33 type sequence G description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 6) chain A residue 34 type sequence A description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 7) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 8) chain A residue 39 type sequence A description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 9) chain A residue 44 type sequence Y description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 10) chain A residue 117 type sequence T description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 11) chain A residue 118 type sequence N description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 12) chain A residue 119 type sequence A description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 13) chain A residue 120 type sequence D description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 14) chain A residue 137 type sequence Q description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 15) chain A residue 140 type sequence Y description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 16) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 17) chain A residue 230 type sequence V description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 18) chain A residue 231 type sequence G description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 19) chain A residue 232 type sequence H description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 20) chain A residue 233 type sequence T description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 21) chain A residue 234 type sequence T description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 22) chain A residue 258 type sequence N description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 23) chain A residue 259 type sequence H description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 24) chain A residue 260 type sequence K description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 25) chain A residue 262 type sequence Y description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 26) chain A residue 278 type sequence H description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 27) chain A residue 279 type sequence I description BINDING SITE FOR RESIDUE NAD A 1294 source : AC2 28) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1295 source : AC3 29) chain A residue 144 type sequence Q description BINDING SITE FOR RESIDUE EDO A 1295 source : AC3 30) chain A residue 188 type sequence E description BINDING SITE FOR RESIDUE EDO A 1295 source : AC3 31) chain A residue 189 type sequence I description BINDING SITE FOR RESIDUE EDO A 1295 source : AC3 32) chain A residue 191 type sequence K description BINDING SITE FOR RESIDUE EDO A 1295 source : AC3 33) chain A residue 72 type sequence D description BINDING SITE FOR RESIDUE EDO A 1296 source : AC4 34) chain A residue 73 type sequence F description BINDING SITE FOR RESIDUE EDO A 1296 source : AC4 35) chain A residue 75 type sequence D description BINDING SITE FOR RESIDUE EDO A 1296 source : AC4 36) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE EDO A 1296 source : AC4 37) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1296 source : AC4 38) chain A residue 60 type sequence Y description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 39) chain A residue 61 type sequence Q description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 40) chain A residue 62 type sequence F description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 41) chain A residue 67 type sequence Q description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 42) chain A residue 71 type sequence F description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 43) chain A residue 124 type sequence W description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 44) chain A residue 75 type sequence D description BINDING SITE FOR RESIDUE GLY A 1298 source : AC6 45) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE GLY A 1298 source : AC6 46) chain A residue 77 type sequence Q description BINDING SITE FOR RESIDUE GLY A 1298 source : AC6 47) chain A residue 110 type sequence K description BINDING SITE FOR RESIDUE GLY A 1299 source : AC7 48) chain A residue 111 type sequence D description BINDING SITE FOR RESIDUE GLY A 1299 source : AC7 49) chain A residue 112 type sequence Y description BINDING SITE FOR RESIDUE GLY A 1299 source : AC7 50) chain A residue 132 type sequence N description BINDING SITE FOR RESIDUE GLY A 1299 source : AC7 51) chain A residue 214 type sequence F description BINDING SITE FOR RESIDUE GLY A 1299 source : AC7

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