eF-site ID 5a3b-A PDB Code 5a3b Chain A click to enlarge Title Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with ADP-ribose Classification TRANSFERASE Compound SIR2 FAMILY PROTEIN Source Streptococcus pyogenes serotype M2 (strain MGAS10270) (Q1JGN6_STRPD) Sequence A:  NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIG PRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRF VALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVA GYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAE QKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHA QKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRV SENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISAT KTIYQK Description Functional site 1) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 2) chain A residue 149 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 3) chain A residue 180 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 4) chain A residue 183 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 5) chain A residue 33 type sequence G description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 6) chain A residue 34 type sequence A description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 7) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 8) chain A residue 39 type sequence A description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 9) chain A residue 66 type sequence L description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 10) chain A residue 117 type sequence T description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 11) chain A residue 137 type sequence Q description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 12) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 13) chain A residue 230 type sequence V description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 14) chain A residue 231 type sequence G description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 15) chain A residue 232 type sequence H description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 16) chain A residue 233 type sequence T description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 17) chain A residue 234 type sequence T description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 18) chain A residue 258 type sequence N description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 19) chain A residue 259 type sequence H description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 20) chain A residue 260 type sequence K description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 21) chain A residue 262 type sequence Y description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 22) chain A residue 278 type sequence H description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 23) chain A residue 279 type sequence I description BINDING SITE FOR RESIDUE APR A 1294 source : AC2 24) chain A residue 13 type sequence T description BINDING SITE FOR RESIDUE EDO A 1295 source : AC3 25) chain A residue 14 type sequence Q description BINDING SITE FOR RESIDUE EDO A 1295 source : AC3 26) chain A residue 277 type sequence E description BINDING SITE FOR RESIDUE EDO A 1295 source : AC3 27) chain A residue 72 type sequence D description BINDING SITE FOR RESIDUE GLY A 1296 source : AC4 28) chain A residue 73 type sequence F description BINDING SITE FOR RESIDUE GLY A 1296 source : AC4 29) chain A residue 75 type sequence D description BINDING SITE FOR RESIDUE GLY A 1296 source : AC4 30) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE GLY A 1296 source : AC4 31) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE GLY A 1296 source : AC4 32) chain A residue 60 type sequence Y description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 33) chain A residue 61 type sequence Q description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 34) chain A residue 124 type sequence W description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 35) chain A residue 236 type sequence Q description BINDING SITE FOR RESIDUE ALA A 1298 source : AC6 36) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE ALA A 1298 source : AC6

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