eF-site ID 5a3a-A PDB Code 5a3a Chain A click to enlarge Title Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes (Apo form) Classification TRANSFERASE Compound SIR2 FAMILY PROTEIN Source Streptococcus pyogenes serotype M2 (strain MGAS10270) (Q1JGN6_STRPD) Sequence A:  NWTTNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIG PRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRF VALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVA GYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAE QKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHA QKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRV SENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISAT KTIYQK Description (1)  SIR2 FAMILY PROTEIN (E.C.2.4.2.30) Functional site 1) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 2) chain A residue 149 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 3) chain A residue 180 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 4) chain A residue 183 type sequence C description BINDING SITE FOR RESIDUE ZN A 1293 source : AC1 5) chain A residue 60 type sequence Y description BINDING SITE FOR RESIDUE GLY A 1294 source : AC2 6) chain A residue 61 type sequence Q description BINDING SITE FOR RESIDUE GLY A 1294 source : AC2 7) chain A residue 67 type sequence Q description BINDING SITE FOR RESIDUE GLY A 1294 source : AC2 8) chain A residue 71 type sequence F description BINDING SITE FOR RESIDUE GLY A 1294 source : AC2 9) chain A residue 125 type sequence V description BINDING SITE FOR RESIDUE GLY A 1294 source : AC2 10) chain A residue 153 type sequence T description BINDING SITE FOR RESIDUE GLY A 1295 source : AC3 11) chain A residue 154 type sequence Y description BINDING SITE FOR RESIDUE GLY A 1295 source : AC3 12) chain A residue 155 type sequence K description BINDING SITE FOR RESIDUE GLY A 1295 source : AC3 13) chain A residue 200 type sequence E description BINDING SITE FOR RESIDUE GLY A 1296 source : AC4 14) chain A residue 204 type sequence F description BINDING SITE FOR RESIDUE GLY A 1296 source : AC4 15) chain A residue 208 type sequence K description BINDING SITE FOR RESIDUE GLY A 1296 source : AC4 16) chain A residue 259 type sequence H description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 17) chain A residue 260 type sequence K description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 18) chain A residue 291 type sequence Q description BINDING SITE FOR RESIDUE GLY A 1297 source : AC5 19) chain A residue 243 type sequence W description BINDING SITE FOR RESIDUE GLY A 1298 source : AC6 20) chain A residue 263 type sequence R description BINDING SITE FOR RESIDUE GLY A 1298 source : AC6 21) chain A residue 44 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1299 source : AC7 22) chain A residue 118 type sequence N description BINDING SITE FOR RESIDUE EDO A 1299 source : AC7 23) chain A residue 119 type sequence A description BINDING SITE FOR RESIDUE EDO A 1299 source : AC7 24) chain A residue 120 type sequence D description BINDING SITE FOR RESIDUE EDO A 1299 source : AC7 25) chain A residue 140 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1299 source : AC7 26) chain A residue 72 type sequence D description BINDING SITE FOR RESIDUE EDO A 1300 source : AC8 27) chain A residue 73 type sequence F description BINDING SITE FOR RESIDUE EDO A 1300 source : AC8 28) chain A residue 75 type sequence D description BINDING SITE FOR RESIDUE EDO A 1300 source : AC8 29) chain A residue 88 type sequence A description BINDING SITE FOR RESIDUE EDO A 1301 source : AC9 30) chain A residue 89 type sequence L description BINDING SITE FOR RESIDUE EDO A 1301 source : AC9 31) chain A residue 93 type sequence D description BINDING SITE FOR RESIDUE EDO A 1301 source : AC9 32) chain A residue 26 type sequence D description BINDING SITE FOR RESIDUE EDO A 1302 source : BC1 33) chain A residue 110 type sequence K description BINDING SITE FOR RESIDUE EDO A 1302 source : BC1 34) chain A residue 111 type sequence D description BINDING SITE FOR RESIDUE EDO A 1302 source : BC1 35) chain A residue 263 type sequence R description BINDING SITE FOR RESIDUE EDO A 1302 source : BC1 36) chain A residue 117 type sequence T description BINDING SITE FOR RESIDUE EDO A 1303 source : BC2 37) chain A residue 67 type sequence Q description BINDING SITE FOR RESIDUE EDO A 1304 source : BC3 38) chain A residue 124 type sequence W description BINDING SITE FOR RESIDUE EDO A 1304 source : BC3 39) chain A residue 127 type sequence G description BINDING SITE FOR RESIDUE EDO A 1304 source : BC3 40) chain A residue 128 type sequence Y description BINDING SITE FOR RESIDUE EDO A 1304 source : BC3 41) chain A residue 129 type sequence D description BINDING SITE FOR RESIDUE EDO A 1305 source : BC4 42) chain A residue 132 type sequence N description BINDING SITE FOR RESIDUE EDO A 1305 source : BC4 43) chain A residue 194 type sequence E description BINDING SITE FOR RESIDUE EDO A 1305 source : BC4

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