eF-site ID 4zzy-A PDB Code 4zzy Chain A click to enlarge Title Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor Classification TRANSFERASE Compound POLY [ADP-RIBOSE] POLYMERASE 2 Source null (PARP2_HUMAN) Sequence A:  ESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKL TVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIP HDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTE LQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTH APTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGS RMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKS ANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQ GKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNGY TLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW Description Functional site 1) chain A residue 328 type sequence S description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 2) chain A residue 331 type sequence I description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 3) chain A residue 332 type sequence Q description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 4) chain A residue 428 type sequence H description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 5) chain A residue 429 type sequence G description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 6) chain A residue 454 type sequence G description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 7) chain A residue 455 type sequence Y description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 8) chain A residue 462 type sequence Y description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 9) chain A residue 463 type sequence F description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 10) chain A residue 464 type sequence A description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 11) chain A residue 469 type sequence K description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 12) chain A residue 470 type sequence S description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 13) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 14) chain A residue 558 type sequence E description BINDING SITE FOR RESIDUE D7N A 1584 source : AC1 15) chain A residue 498-505 type prosite sequence LLEANPKA description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANPKA source prosite : PS00867 16) chain A residue 558 type ACT_SITE sequence E description For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:26704974, ECO:0000305|PubMed:30104678, ECO:0000305|PubMed:32028527 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 437 type BINDING sequence G description BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 444 type BINDING sequence R description BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 470 type BINDING sequence S description BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 428 type BINDING sequence H description BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 232 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 428-442 type prosite sequence HGSRMSNWVGILSHG description CASPASE_HIS Caspase family histidine active site. HgsrmSnwVgILSHG source prosite : PS01121

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