eF-site ID 4zzx-B PDB Code 4zzx Chain B click to enlarge Title Structure of PARP2 catalytic domain bound to an isoindolinone inhibitor Classification TRANSFERASE Compound POLY [ADP-RIBOSE] POLYMERASE 2 Source (PARP2_HUMAN) Sequence B:  QLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTV AQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHD FGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQ SHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTH SDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSN WVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYC FASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHS TKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTL NYNEYIVYNPNQVRMRYLLKVQFNFLQLW Description Functional site 1) chain B residue 328 type sequence S description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 2) chain B residue 331 type sequence I description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 3) chain B residue 428 type sequence H description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 4) chain B residue 429 type sequence G description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 5) chain B residue 454 type sequence G description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 6) chain B residue 462 type sequence Y description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 7) chain B residue 463 type sequence F description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 8) chain B residue 470 type sequence S description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 9) chain B residue 473 type sequence Y description BINDING SITE FOR RESIDUE FSU B 1584 source : AC2 10) chain B residue 428 type BINDING sequence H description BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 437 type BINDING sequence G description BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 444 type BINDING sequence R description BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 470 type BINDING sequence S description BINDING => ECO:0000269|PubMed:32028527, ECO:0007744|PDB:6TX3 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 558 type ACT_SITE sequence E description For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:26704974, ECO:0000305|PubMed:30104678, ECO:0000305|PubMed:32028527 source Swiss-Prot : SWS_FT_FI1

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