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|
eF-site ID
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4zvp-C |
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PDB Code
|
4zvp |
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Chain
|
C |
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click to enlarge
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Title
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Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to DEVD inhibitor. |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Caspase-7 |
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Source
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(4ZVP) |
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Sequence
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C: |
TYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEA
LFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAAC
FACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLE
KPKLFFIQACRGTELDDGIQ
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Description
|
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Functional site
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|
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1)
|
chain |
C |
| residue |
454 |
| type |
SITE |
| sequence |
D
|
| description |
Involved in allosteric regulation => ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:19581639
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
2)
|
chain |
C |
| residue |
490 |
| type |
SITE |
| sequence |
E
|
| description |
Involved in allosteric regulation => ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:19581639
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
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3)
|
chain |
C |
| residue |
440 |
| type |
MOD_RES |
| sequence |
I
|
| description |
Phosphothreonine; by PAK2 => ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:27889207
|
| source |
Swiss-Prot : SWS_FT_FI6
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