|
|
eF-site ID
|
4zvp-A |
|
PDB Code
|
4zvp |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to DEVD inhibitor. |
|
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
|
Compound
|
Caspase-7 |
|
Source
|
(4ZVP) |
|
|
Sequence
|
A: |
YQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEAL
FKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACF
ACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEK
PKLFFIQACRGTELDDGIQ
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
154 |
| type |
SITE |
| sequence |
D
|
| description |
Involved in allosteric regulation => ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:19581639
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
2)
|
chain |
A |
| residue |
190 |
| type |
SITE |
| sequence |
E
|
| description |
Involved in allosteric regulation => ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:19581639
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
3)
|
chain |
A |
| residue |
140 |
| type |
MOD_RES |
| sequence |
I
|
| description |
Phosphothreonine; by PAK2 => ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:27889207
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
4)
|
chain |
A |
| residue |
131-145 |
| type |
prosite |
| sequence |
HTNAACFACILLSHG
|
| description |
CASPASE_HIS Caspase family histidine active site. HtnaaCfaCiLLSHG
|
| source |
prosite : PS01121
|
|
|
5)
|
chain |
A |
| residue |
177-188 |
| type |
prosite |
| sequence |
KPKLFFIQACRG
|
| description |
CASPASE_CYS Caspase family cysteine active site. KPKLFFIQACRG
|
| source |
prosite : PS01122
|
|
|
|