eF-site ID 4zup-B PDB Code 4zup Chain B click to enlarge Title Crystal structure of acetylpolyamine amidohydrolase from Mycoplana ramosa in complex with a hydroxamate inhibitor Classification Hydrolase/Hydrolase inhibitor Compound Acetylpolyamine aminohydrolase Source (APHA_MYCRA) Sequence B:  MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAV KEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKA AGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAI SPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHA GIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGN GTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAG AGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVS LGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVME GGYGVPEIGLNVANVLKGVAG Description Functional site 1) chain B residue 100 type sequence R description binding site for residue GOL A 409 source : AC9 2) chain B residue 195 type sequence D description binding site for residue ZN B 401 source : AD1 3) chain B residue 197 type sequence H description binding site for residue ZN B 401 source : AD1 4) chain B residue 284 type sequence D description binding site for residue ZN B 401 source : AD1 5) chain B residue 146 type sequence H description binding site for residue ZN B 402 source : AD2 6) chain B residue 193 type sequence D description binding site for residue K B 403 source : AD3 7) chain B residue 195 type sequence D description binding site for residue K B 403 source : AD3 8) chain B residue 197 type sequence H description binding site for residue K B 403 source : AD3 9) chain B residue 216 type sequence S description binding site for residue K B 403 source : AD3 10) chain B residue 217 type sequence L description binding site for residue K B 403 source : AD3 11) chain B residue 206 type sequence F description binding site for residue K B 404 source : AD4 12) chain B residue 209 type sequence R description binding site for residue K B 404 source : AD4 13) chain B residue 212 type sequence V description binding site for residue K B 404 source : AD4 14) chain B residue 243 type sequence T description binding site for residue K B 404 source : AD4 15) chain B residue 117 type sequence E description binding site for residue 5XA B 405 source : AD5 16) chain B residue 158 type sequence H description binding site for residue 5XA B 405 source : AD5 17) chain B residue 159 type sequence H description binding site for residue 5XA B 405 source : AD5 18) chain B residue 167 type sequence G description binding site for residue 5XA B 405 source : AD5 19) chain B residue 168 type sequence Y description binding site for residue 5XA B 405 source : AD5 20) chain B residue 195 type sequence D description binding site for residue 5XA B 405 source : AD5 21) chain B residue 197 type sequence H description binding site for residue 5XA B 405 source : AD5 22) chain B residue 225 type sequence F description binding site for residue 5XA B 405 source : AD5 23) chain B residue 284 type sequence D description binding site for residue 5XA B 405 source : AD5 24) chain B residue 323 type sequence Y description binding site for residue 5XA B 405 source : AD5 25) chain B residue 96 type sequence R description binding site for residue GOL B 406 source : AD6 26) chain B residue 1 type sequence M description binding site for residue NO3 B 407 source : AD7 27) chain B residue 45 type sequence F description binding site for residue NO3 B 407 source : AD7 28) chain B residue 340 type sequence A description binding site for residue NO3 B 407 source : AD7 29) chain B residue 1 type sequence M description binding site for residue NO3 B 408 source : AD8 30) chain B residue 146 type sequence H description binding site for residue NO3 B 408 source : AD8 31) chain B residue 147 type sequence K description binding site for residue NO3 B 408 source : AD8 32) chain B residue 148 type sequence A description binding site for residue NO3 B 408 source : AD8 33) chain B residue 266 type sequence L description binding site for residue GOL B 409 source : AD9 34) chain B residue 307 type sequence T description binding site for residue GOL B 409 source : AD9 35) chain B residue 310 type sequence A description binding site for residue GOL B 409 source : AD9 36) chain B residue 311 type sequence S description binding site for residue GOL B 409 source : AD9 37) chain B residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000305|PubMed:21268586, ECO:0000305|PubMed:26200446 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 117 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21268586, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI2 39) chain B residue 323 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21268586, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI2 40) chain B residue 19 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21268586, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI2 41) chain B residue 106 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21268586, ECO:0007744|PDB:3Q9C source Swiss-Prot : SWS_FT_FI3 42) chain B residue 195 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21268586, ECO:0000269|PubMed:26200446, ECO:0007744|PDB:3Q9B, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI4 43) chain B residue 197 type BINDING sequence H description BINDING => ECO:0000269|PubMed:21268586, ECO:0000269|PubMed:26200446, ECO:0007744|PDB:3Q9B, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI4 44) chain B residue 284 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21268586, ECO:0000269|PubMed:26200446, ECO:0007744|PDB:3Q9B, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI4 45) chain B residue 323 type SITE sequence Y description Polarizes the scissile carbonyl of the substrate => ECO:0000305|PubMed:21268586 source Swiss-Prot : SWS_FT_FI5

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