eF-site ID 4zup-A PDB Code 4zup Chain A click to enlarge Title Crystal structure of acetylpolyamine amidohydrolase from Mycoplana ramosa in complex with a hydroxamate inhibitor Classification Hydrolase/Hydrolase inhibitor Compound Acetylpolyamine aminohydrolase Source (APHA_MYCRA) Sequence A:  MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAV KEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKA AGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAI SPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHA GIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGN GTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAG AGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVS LGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVME GGYGVPEIGLNVANVLKGVAG Description Functional site 1) chain A residue 195 type sequence D description binding site for residue ZN A 401 source : AC1 2) chain A residue 197 type sequence H description binding site for residue ZN A 401 source : AC1 3) chain A residue 284 type sequence D description binding site for residue ZN A 401 source : AC1 4) chain A residue 146 type sequence H description binding site for residue ZN A 402 source : AC2 5) chain A residue 193 type sequence D description binding site for residue K A 403 source : AC3 6) chain A residue 195 type sequence D description binding site for residue K A 403 source : AC3 7) chain A residue 197 type sequence H description binding site for residue K A 403 source : AC3 8) chain A residue 216 type sequence S description binding site for residue K A 403 source : AC3 9) chain A residue 217 type sequence L description binding site for residue K A 403 source : AC3 10) chain A residue 206 type sequence F description binding site for residue K A 404 source : AC4 11) chain A residue 209 type sequence R description binding site for residue K A 404 source : AC4 12) chain A residue 212 type sequence V description binding site for residue K A 404 source : AC4 13) chain A residue 243 type sequence T description binding site for residue K A 404 source : AC4 14) chain A residue 117 type sequence E description binding site for residue 5XA A 405 source : AC5 15) chain A residue 158 type sequence H description binding site for residue 5XA A 405 source : AC5 16) chain A residue 159 type sequence H description binding site for residue 5XA A 405 source : AC5 17) chain A residue 168 type sequence Y description binding site for residue 5XA A 405 source : AC5 18) chain A residue 195 type sequence D description binding site for residue 5XA A 405 source : AC5 19) chain A residue 197 type sequence H description binding site for residue 5XA A 405 source : AC5 20) chain A residue 225 type sequence F description binding site for residue 5XA A 405 source : AC5 21) chain A residue 284 type sequence D description binding site for residue 5XA A 405 source : AC5 22) chain A residue 323 type sequence Y description binding site for residue 5XA A 405 source : AC5 23) chain A residue 15 type sequence K description binding site for residue GOL A 406 source : AC6 24) chain A residue 75 type sequence W description binding site for residue GOL A 406 source : AC6 25) chain A residue 84 type sequence K description binding site for residue GOL A 406 source : AC6 26) chain A residue 85 type sequence G description binding site for residue GOL A 406 source : AC6 27) chain A residue 1 type sequence M description binding site for residue NO3 A 407 source : AC7 28) chain A residue 45 type sequence F description binding site for residue NO3 A 407 source : AC7 29) chain A residue 340 type sequence A description binding site for residue NO3 A 407 source : AC7 30) chain A residue 1 type sequence M description binding site for residue NO3 A 408 source : AC8 31) chain A residue 146 type sequence H description binding site for residue NO3 A 408 source : AC8 32) chain A residue 147 type sequence K description binding site for residue NO3 A 408 source : AC8 33) chain A residue 148 type sequence A description binding site for residue NO3 A 408 source : AC8 34) chain A residue 231 type sequence Y description binding site for residue GOL A 409 source : AC9 35) chain A residue 232 type sequence A description binding site for residue GOL A 409 source : AC9 36) chain A residue 233 type sequence E description binding site for residue GOL A 409 source : AC9 37) chain A residue 19 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21268586, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI2 38) chain A residue 117 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21268586, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI2 39) chain A residue 323 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21268586, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI2 40) chain A residue 159 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000305|PubMed:21268586, ECO:0000305|PubMed:26200446 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 106 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21268586, ECO:0007744|PDB:3Q9C source Swiss-Prot : SWS_FT_FI3 42) chain A residue 195 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21268586, ECO:0000269|PubMed:26200446, ECO:0007744|PDB:3Q9B, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI4 43) chain A residue 197 type BINDING sequence H description BINDING => ECO:0000269|PubMed:21268586, ECO:0000269|PubMed:26200446, ECO:0007744|PDB:3Q9B, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI4 44) chain A residue 284 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21268586, ECO:0000269|PubMed:26200446, ECO:0007744|PDB:3Q9B, ECO:0007744|PDB:3Q9E source Swiss-Prot : SWS_FT_FI4 45) chain A residue 323 type SITE sequence Y description Polarizes the scissile carbonyl of the substrate => ECO:0000305|PubMed:21268586 source Swiss-Prot : SWS_FT_FI5

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