eF-site ID 4zr2-AB
PDB Code 4zr2
Chain A, B

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Title Crystal Structure of the Domain-Swapped Dimer K40L:Q108K:Y60W mutant of Human Cellular Retinol Binding Protein II
Classification LIPID BINDING PROTEIN
Compound Retinol-binding protein 2
Source (RET2_HUMAN)
Sequence A:  TRDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTL
VIDQDGDNFKTKTTSTFRNWDVDFTVGVEFDEYTKSLDNR
HVKALVTWEGDVLVCVQKGEKENRGWKKWIEGDKLYLELT
CGDQVCRQVFKKK
B:  TRDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTL
VIDQDGDNFKTKTTSTFRNWDVDFTVGVEFDEYTKSLDNR
HVKALVTWEGDVLVCVQKGEKENRGWKKWIEGDKLYLELT
CGDQVCRQVFKKK
Description


Functional site

1) chain A
residue 108
type
sequence K
description binding site for residue RET A 201
source : AC1

2) chain A
residue 107
type
sequence K
description binding site for residue ACT A 202
source : AC2

3) chain A
residue 109
type
sequence W
description binding site for residue ACT A 202
source : AC2

4) chain B
residue 62
type
sequence V
description binding site for residue ACT A 202
source : AC2

5) chain B
residue 63
type
sequence D
description binding site for residue ACT A 202
source : AC2

6) chain A
residue 100
type
sequence E
description binding site for residue ACT A 203
source : AC3

7) chain A
residue 102
type
sequence E
description binding site for residue ACT A 203
source : AC3

8) chain A
residue 69
type
sequence E
description binding site for residue ACT B 201
source : AC4

9) chain B
residue 89
type
sequence E
description binding site for residue ACT B 201
source : AC4

10) chain B
residue 107
type
sequence K
description binding site for residue ACT B 201
source : AC4

11) chain B
residue 91
type
sequence D
description binding site for residue ACT B 202
source : AC5

12) chain B
residue 92
type
sequence V
description binding site for residue ACT B 202
source : AC5

13) chain B
residue 109
type
sequence W
description binding site for residue ACT B 202
source : AC5

14) chain B
residue 110
type
sequence I
description binding site for residue ACT B 202
source : AC5

15) chain B
residue 109
type
sequence W
description binding site for residue ACT B 203
source : AC6

16) chain A
residue 6-23
type prosite
sequence GTWEMESNENFEGYMKAL
description FABP Cytosolic fatty-acid binding proteins signature. GTWeMesNeNFEgYMKAL
source prosite : PS00214

17) chain A
residue 40
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:18076076
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 108
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:18076076
source Swiss-Prot : SWS_FT_FI1

19) chain B
residue 40
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:18076076
source Swiss-Prot : SWS_FT_FI1

20) chain B
residue 108
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:18076076
source Swiss-Prot : SWS_FT_FI1


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