eF-site ID 4zph-ABCD PDB Code 4zph Chain A, B, C, D click to enlarge Title Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine Classification PROTEIN TRANSPORT/TRANSCRIPTION Compound Aryl hydrocarbon receptor nuclear translocator Source Mus musculus (Mouse) (EPAS1_MOUSE) Sequence A:  ERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVS HMKSLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVT PVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSRRSFIC RMRCPHFVVVHCTGYIKAFCLVAIGRLQVPTEFISRHNIE GIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRD SFQQVVKLKGQVLSVMFRFRSKTREWLWMRTSSFTFQNPY SDEIEYIICTNTNV B:  RRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLR THKLLSSVCSMDNLYLKALEGFIAVVTQDGDMIFLSENIS KFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLSTERDFF MRMKCTVGRTVNLKSATWKVLHCTGQVRVLSCLIIMCEPI QHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHP EELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRM LAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEK NDVVFSMDQTES C:  ERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVS HMKSTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTP VLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSRRSFICR MRCPHFVVVHCTGYIKAFCLVAIGRLQPTEFISRHNIEGI FTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSF QQVVKLKGQVLSVMFRFRSKTREWLWMRTSSFTFQNPYSD EIEYIICTNTNV D:  CRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFL RTHKLLSSVCSMDNLYLKALEGFIAVVTQDGDMIFLSENI SKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLVSTERD FFMRMKCTVTGRTVLKSATWKVLHCTGQVRVLSCLIIMCE PIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGY HPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQY RMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEI EKNDVVFSMDQTES Description Functional site 1) chain A residue 266 type sequence R description binding site for residue PRL A 501 source : AC1 2) chain A residue 305 type sequence V description binding site for residue PRL A 501 source : AC1 3) chain B residue 306 type sequence Q description binding site for residue PRL A 501 source : AC1 4) chain B residue 344 type sequence L description binding site for residue PRL A 501 source : AC1 5) chain B residue 345 type sequence S description binding site for residue PRL A 501 source : AC1

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