eF-site ID 4zn9-A PDB Code 4zn9 Chain A click to enlarge Title Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Oxabicyclic Heptene Sulfonate (OBHS) Classification TRANSCRIPTION Compound Estrogen receptor Source Homo sapiens (Human) (NCOA2_HUMAN) Sequence A:  SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMG LLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWL EILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEI FDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYDHIHR VLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHM SNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTS Description Functional site 1) chain A residue 346 type sequence L description binding site for residue OBH A 601 source : AC1 2) chain A residue 347 type sequence T description binding site for residue OBH A 601 source : AC1 3) chain A residue 353 type sequence E description binding site for residue OBH A 601 source : AC1 4) chain A residue 387 type sequence L description binding site for residue OBH A 601 source : AC1 5) chain A residue 388 type sequence M description binding site for residue OBH A 601 source : AC1 6) chain A residue 394 type sequence R description binding site for residue OBH A 601 source : AC1 7) chain A residue 404 type sequence F description binding site for residue OBH A 601 source : AC1 8) chain A residue 420 type sequence G description binding site for residue OBH A 601 source : AC1 9) chain A residue 421 type sequence M description binding site for residue OBH A 601 source : AC1 10) chain A residue 424 type sequence I description binding site for residue OBH A 601 source : AC1 11) chain A residue 521 type sequence G description binding site for residue OBH A 601 source : AC1 12) chain A residue 524 type sequence H description binding site for residue OBH A 601 source : AC1 13) chain A residue 525 type sequence L description binding site for residue OBH A 601 source : AC1 14) chain A residue 537 type MOD_RES sequence S description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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