eF-site ID 4zl4-B PDB Code 4zl4 Chain B click to enlarge Title Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842) Classification hydrolase/hydrolase inhibitor Compound Aspartic protease PM5 Source (Q6PRR9_PLAVI) Sequence B:  KDLLYKYKLYGDIDEYAYYFLDIDIGTPEQRISLILDTGS SSLSFPCAGCKNCGVHMENPFNLNNSKTSSILYCENEECP FKLNCVKGKCEYMQSYCEGSQISGFYFSDVVSVVSYNNER VTFRKLMGCHMHEESLFLYQQATGVLGMSLSKPQGIPTFV NLLFDNAPQLKQVFTICISENGGELIAGGYDPAYIVRAEK VVWENVTRKYYYYIKVRGLDMFGTNMMSSSKGLEMLVDSG STFTHIPEDLYNKLNYFFDILCIQDMNNAYDVNKRLKMTN ESFNNPLVQFDDFRKSLKSIIAKENMCVKIVDGVQCWKYL EGLPDLFVTLSNNYKMKWQPHSYLYKKESFWCKGIEKQVN NKPILGLTFFKNRQVIFDIQKNRIGFVDANCPSHP Description Functional site 1) chain B residue 342 type sequence N description binding site for residue 4PK A 501 source : AC1 2) chain B residue 343 type sequence N description binding site for residue 4PK A 501 source : AC1 3) chain B residue 60 type sequence A description binding site for residue 4PK B 501 source : AC9 4) chain B residue 80 type sequence D description binding site for residue 4PK B 501 source : AC9 5) chain B residue 82 type sequence G description binding site for residue 4PK B 501 source : AC9 6) chain B residue 137 type sequence Q description binding site for residue 4PK B 501 source : AC9 7) chain B residue 139 type sequence Y description binding site for residue 4PK B 501 source : AC9 8) chain B residue 140 type sequence C description binding site for residue 4PK B 501 source : AC9 9) chain B residue 141 type sequence E description binding site for residue 4PK B 501 source : AC9 10) chain B residue 179 type sequence L description binding site for residue 4PK B 501 source : AC9 11) chain B residue 180 type sequence F description binding site for residue 4PK B 501 source : AC9 12) chain B residue 183 type sequence Q description binding site for residue 4PK B 501 source : AC9 13) chain B residue 288 type sequence Y description binding site for residue 4PK B 501 source : AC9 14) chain B residue 313 type sequence D description binding site for residue 4PK B 501 source : AC9 15) chain B residue 315 type sequence G description binding site for residue 4PK B 501 source : AC9 16) chain B residue 316 type sequence S description binding site for residue 4PK B 501 source : AC9 17) chain B residue 317 type sequence T description binding site for residue 4PK B 501 source : AC9 18) chain B residue 320 type sequence H description binding site for residue 4PK B 501 source : AC9 19) chain B residue 439 type sequence I description binding site for residue 4PK B 501 source : AC9 20) chain B residue 83 type sequence S description binding site for residue SO4 B 502 source : AD1 21) chain B residue 84 type sequence S description binding site for residue SO4 B 502 source : AD1 22) chain B residue 137 type sequence Q description binding site for residue SO4 B 502 source : AD1 23) chain B residue 322 type sequence P description binding site for residue SO4 B 503 source : AD2 24) chain B residue 323 type sequence E description binding site for residue SO4 B 503 source : AD2 25) chain B residue 433 type sequence Q description binding site for residue SO4 B 503 source : AD2 26) chain B residue 51 type sequence K description binding site for residue SO4 B 504 source : AD3 27) chain B residue 53 type sequence Y description binding site for residue SO4 B 504 source : AD3 28) chain B residue 469 type sequence H description binding site for residue SO4 B 504 source : AD3 29) chain B residue 470 type sequence P description binding site for residue SO4 B 504 source : AD3 30) chain B residue 278 type sequence W description binding site for residue SO4 B 505 source : AD4 31) chain B residue 458 type sequence R description binding site for residue SO4 B 505 source : AD4 32) chain B residue 84 type sequence S description binding site for residue EDO B 506 source : AD5 33) chain B residue 194 type sequence S description binding site for residue EDO B 506 source : AD5 34) chain B residue 195 type sequence K description binding site for residue EDO B 506 source : AD5 35) chain B residue 198 type sequence G description binding site for residue EDO B 506 source : AD5 36) chain B residue 199 type sequence I description binding site for residue EDO B 506 source : AD5 37) chain B residue 233 type sequence Y description binding site for residue EDO B 507 source : AD6 38) chain B residue 273 type sequence A description binding site for residue EDO B 507 source : AD6 39) chain B residue 274 type sequence E description binding site for residue EDO B 507 source : AD6 40) chain B residue 275 type sequence K description binding site for residue EDO B 507 source : AD6 41) chain B residue 276 type sequence V description binding site for residue EDO B 507 source : AD6 42) chain B residue 117 type sequence C description binding site for residue 4PF B 508 source : AD7 43) chain B residue 117 type sequence C description binding site for residue 4PF B 508 source : AD7 44) chain B residue 118 type sequence E description binding site for residue 4PF B 508 source : AD7 45) chain B residue 120 type sequence E description binding site for residue 4PF B 508 source : AD7 46) chain B residue 121 type sequence E description binding site for residue 4PF B 508 source : AD7 47) chain B residue 121 type sequence E description binding site for residue 4PF B 508 source : AD7 48) chain B residue 122 type sequence C description binding site for residue 4PF B 508 source : AD7 49) chain B residue 122 type sequence C description binding site for residue 4PF B 508 source : AD7 50) chain B residue 126 type sequence L description binding site for residue 4PF B 508 source : AD7 51) chain B residue 128 type sequence C description binding site for residue 4PF B 508 source : AD7 52) chain B residue 128 type sequence C description binding site for residue 4PF B 508 source : AD7 53) chain B residue 80 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103 source Swiss-Prot : SWS_FT_FI1 54) chain B residue 313 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103 source Swiss-Prot : SWS_FT_FI1

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