eF-site ID 4zl4-A PDB Code 4zl4 Chain A click to enlarge Title Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842) Classification hydrolase/hydrolase inhibitor Compound Aspartic protease PM5 Source (Q6PRR9_PLAVI) Sequence A:  KDLLYKYKLYGDIDEYAYYFLDIDIGTPEQRISLILDTGS SSLSFPCAGCKNCGVHMENPFNLNNSKTSSILYCENEECP FKLNCVKGKCEYMQSYCEGSQISGFYFSDVVSVVSYNNER VTFRKLMGCHMHEESLFLYQQATGVLGMSLSKPQGIPTFV NLLFDNAPQLKQVFTICISENGGELIAGGYDPAYIVRAEK VVWENVTRKYYYYIKVRGLDMFGTNMMSSSKGLEMLVDSG STFTHIPEDLYNKLNYFFDILCIQDMNNAYDVNKRLKMTN ESFNNPLVQFDDFRKSLKSIIAKENMCVKIVDGVQCWKYL EGLPDLFVTLSNNYKMKWQPHSYLYKKESFWCKGIEKQVN NKPILGLTFFKNRQVIFDIQKNRIGFVDANCPSHP Description Functional site 1) chain A residue 60 type sequence A description binding site for residue 4PK A 501 source : AC1 2) chain A residue 80 type sequence D description binding site for residue 4PK A 501 source : AC1 3) chain A residue 82 type sequence G description binding site for residue 4PK A 501 source : AC1 4) chain A residue 137 type sequence Q description binding site for residue 4PK A 501 source : AC1 5) chain A residue 139 type sequence Y description binding site for residue 4PK A 501 source : AC1 6) chain A residue 140 type sequence C description binding site for residue 4PK A 501 source : AC1 7) chain A residue 141 type sequence E description binding site for residue 4PK A 501 source : AC1 8) chain A residue 179 type sequence L description binding site for residue 4PK A 501 source : AC1 9) chain A residue 180 type sequence F description binding site for residue 4PK A 501 source : AC1 10) chain A residue 183 type sequence Q description binding site for residue 4PK A 501 source : AC1 11) chain A residue 313 type sequence D description binding site for residue 4PK A 501 source : AC1 12) chain A residue 315 type sequence G description binding site for residue 4PK A 501 source : AC1 13) chain A residue 316 type sequence S description binding site for residue 4PK A 501 source : AC1 14) chain A residue 317 type sequence T description binding site for residue 4PK A 501 source : AC1 15) chain A residue 439 type sequence I description binding site for residue 4PK A 501 source : AC1 16) chain A residue 322 type sequence P description binding site for residue SO4 A 502 source : AC2 17) chain A residue 323 type sequence E description binding site for residue SO4 A 502 source : AC2 18) chain A residue 433 type sequence Q description binding site for residue SO4 A 502 source : AC2 19) chain A residue 51 type sequence K description binding site for residue SO4 A 503 source : AC3 20) chain A residue 469 type sequence H description binding site for residue SO4 A 503 source : AC3 21) chain A residue 470 type sequence P description binding site for residue SO4 A 503 source : AC3 22) chain A residue 278 type sequence W description binding site for residue SO4 A 504 source : AC4 23) chain A residue 458 type sequence R description binding site for residue SO4 A 504 source : AC4 24) chain A residue 84 type sequence S description binding site for residue EDO A 505 source : AC5 25) chain A residue 137 type sequence Q description binding site for residue EDO A 505 source : AC5 26) chain A residue 195 type sequence K description binding site for residue EDO A 505 source : AC5 27) chain A residue 286 type sequence Y description binding site for residue EDO A 505 source : AC5 28) chain A residue 338 type sequence I description binding site for residue EDO A 506 source : AC6 29) chain A residue 339 type sequence Q description binding site for residue EDO A 506 source : AC6 30) chain A residue 340 type sequence D description binding site for residue EDO A 506 source : AC6 31) chain A residue 341 type sequence M description binding site for residue EDO A 506 source : AC6 32) chain A residue 381 type sequence M description binding site for residue EDO A 506 source : AC6 33) chain A residue 382 type sequence C description binding site for residue EDO A 506 source : AC6 34) chain A residue 383 type sequence V description binding site for residue EDO A 506 source : AC6 35) chain A residue 84 type sequence S description binding site for residue EDO A 507 source : AC7 36) chain A residue 194 type sequence S description binding site for residue EDO A 507 source : AC7 37) chain A residue 195 type sequence K description binding site for residue EDO A 507 source : AC7 38) chain A residue 198 type sequence G description binding site for residue EDO A 507 source : AC7 39) chain A residue 199 type sequence I description binding site for residue EDO A 507 source : AC7 40) chain A residue 233 type sequence Y description binding site for residue EDO A 508 source : AC8 41) chain A residue 453 type sequence D description binding site for residue EDO A 508 source : AC8 42) chain A residue 458 type sequence R description binding site for residue EDO A 508 source : AC8 43) chain A residue 342 type sequence N description binding site for residue 4PK B 501 source : AC9 44) chain A residue 343 type sequence N description binding site for residue 4PK B 501 source : AC9 45) chain A residue 80 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 313 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 77-88 type prosite sequence LILDTGSSSLSF description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LILDTGSSSLSF source prosite : PS00141 48) chain A residue 310-321 type prosite sequence MLVDSGSTFTHI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LILDTGSSSLSF source prosite : PS00141

Display surface Download Links