eF-site ID 4zhm-U PDB Code 4zhm Chain U click to enlarge Title The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4 Classification HYDROLASE INHIBITOR/HYDROLASE Compound mupain-1-16-IG Source Homo sapiens (Human) (UROK_HUMAN) Sequence U:  IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCW VISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVEN LILHKDYSADTLAYHNDIALLKIRSKEGRCAQPSRTIQTI ALPSMYNDPQFGTSCEITGFGKEQSTDYLYPEQLKMTVVK LISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPW IRSHTKE Description (1)  mupain-1-16-IG, Urokinase-type plasminogen activator (E.C.3.4.21.73) Functional site 1) chain U residue 189 type sequence D description binding site for residue MRZ P 100 source : AC1 2) chain U residue 190 type sequence S description binding site for residue MRZ P 100 source : AC1 3) chain U residue 213 type sequence V description binding site for residue MRZ P 100 source : AC1 4) chain U residue 216 type sequence G description binding site for residue MRZ P 100 source : AC1 5) chain U residue 219 type sequence G description binding site for residue MRZ P 100 source : AC1 6) chain U residue 220 type sequence C description binding site for residue MRZ P 100 source : AC1 7) chain U residue 226 type sequence G description binding site for residue MRZ P 100 source : AC1 8) chain U residue 145 type CARBOHYD sequence Q description N-linked (GlcNAc...) asparagine source Swiss-Prot : SWS_FT_FI3 9) chain U residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 10) chain U residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 11) chain U residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 12) chain U residue 146 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:9151681 source Swiss-Prot : SWS_FT_FI2 13) chain U residue 53-58 type prosite sequence ISATHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC source prosite : PS00134 14) chain U residue 189-200 type prosite sequence DSCQGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV source prosite : PS00135

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