eF-site ID 4zel-AB PDB Code 4zel Chain A, B click to enlarge Title Human dopamine beta-hydroxylase Classification OXIDOREDUCTASE Compound Dopamine beta-hydroxylase Source Homo sapiens (Human) (DOPO_HUMAN) Sequence A:  PLPYHIPLDPEGSLELSWNVSYTQEAIHFQLLVRRLKAGV LFGMSDRGELENADLVVLWTDGDAYFADAWSDQKGQIHLD PQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTV HLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPE LPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHI IKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSK MKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSR YLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGIME LGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHI FASQLHTHLTGRKVVTVLVRDGREWEIVNQDNHYSPHFQE IRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEE MCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNED VCTCPQASVSQQFTSVPWNSFNRDVLKALYSFAPISMHCN KSSAVRFQGEWNLQPLPKVISTLEEPTVVS B:  PLPYHIPLDPEGSLELSWNVSYTQEAIHFQLLVRRLKAGV LFGMSDRGELENADLVVLAYFADAWSDQKGQIHLDPQQDY QLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYG ILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDA CTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEP IVTKGNEALVHHMEVFQCAPEVPHFSGPCDSKMLNYCRHV LAAWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPL VIEGRNDSSGIRLYYTAKLRRFNAGIMELGLVYTPVMAIP PRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGR KVVTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHP GDVLITSCTYNTEDRELATVGGFGILEEMCVNYVHYYPQT QLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQ FTSVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWN LQPLPKVISTLEEPTPQCVVSIGG Description (1)  dopamine beta hydroxylase Functional site 1) chain A residue 412 type ligand sequence H description binding site for residue CU A 701 source : AC1 2) chain A residue 414 type ligand sequence H description binding site for residue CU A 701 source : AC1 3) chain A residue 487 type ligand sequence M description binding site for residue CU A 701 source : AC1 4) chain A residue 47 type ligand sequence L description binding site for Mono-Saccharide NAG A 702 bound to ASN A 64 source : AC2 5) chain A residue 64 type ligand sequence N description binding site for Mono-Saccharide NAG A 702 bound to ASN A 64 source : AC2 6) chain A residue 65 type ligand sequence V description binding site for Mono-Saccharide NAG A 702 bound to ASN A 64 source : AC2 7) chain A residue 177 type ligand sequence F description binding site for Poly-Saccharide residues NAG A 705 through BMA A 707 bound to ASN A 184 source : AC3 8) chain A residue 184 type ligand sequence N description binding site for Poly-Saccharide residues NAG A 705 through BMA A 707 bound to ASN A 184 source : AC3 9) chain A residue 186 type ligand sequence S description binding site for Poly-Saccharide residues NAG A 705 through BMA A 707 bound to ASN A 184 source : AC3 10) chain B residue 570 type ligand sequence A description binding site for Poly-Saccharide residues NAG A 705 through BMA A 707 bound to ASN A 184 source : AC3 11) chain B residue 571 type ligand sequence V description binding site for Poly-Saccharide residues NAG A 705 through BMA A 707 bound to ASN A 184 source : AC3 12) chain A residue 370 type ligand sequence V description binding site for Poly-Saccharide residues NAG A 703 through NAG A 704 bound to ASN A 566 source : AC4 13) chain A residue 502 type ligand sequence L description binding site for Poly-Saccharide residues NAG A 703 through NAG A 704 bound to ASN A 566 source : AC4 14) chain A residue 564 type ligand sequence H description binding site for Poly-Saccharide residues NAG A 703 through NAG A 704 bound to ASN A 566 source : AC4 15) chain A residue 566 type ligand sequence N description binding site for Poly-Saccharide residues NAG A 703 through NAG A 704 bound to ASN A 566 source : AC4 16) chain A residue 570 type ligand sequence A description binding site for Poly-Saccharide residues NAG A 703 through NAG A 704 bound to ASN A 566 source : AC4 17) chain A residue 572 type ligand sequence R description binding site for Poly-Saccharide residues NAG A 703 through NAG A 704 bound to ASN A 566 source : AC4 18) chain B residue 64 type ligand sequence N description binding site for Mono-Saccharide NAG B 705 bound to ASN B 64 source : AC5 19) chain B residue 65 type ligand sequence V description binding site for Mono-Saccharide NAG B 705 bound to ASN B 64 source : AC5 20) chain B residue 206 type ligand sequence E description binding site for Mono-Saccharide NAG B 705 bound to ASN B 64 source : AC5 21) chain A residue 92 type ligand sequence R description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 22) chain A residue 185 type ligand sequence G description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 23) chain A residue 190 type ligand sequence M description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 24) chain A residue 418 type ligand sequence R description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 25) chain A residue 469 type ligand sequence N description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 26) chain A residue 471 type ligand sequence E description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 27) chain B residue 220 type ligand sequence N description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 28) chain B residue 221 type ligand sequence I description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 29) chain B residue 344 type ligand sequence N description binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344 source : AC6 30) chain B residue 502 type ligand sequence L description binding site for Poly-Saccharide residues NAG B 706 through BMA B 708 bound to ASN B 566 source : AC7 31) chain B residue 564 type ligand sequence H description binding site for Poly-Saccharide residues NAG B 706 through BMA B 708 bound to ASN B 566 source : AC7 32) chain B residue 566 type ligand sequence N description binding site for Poly-Saccharide residues NAG B 706 through BMA B 708 bound to ASN B 566 source : AC7 33) chain B residue 569 type ligand sequence S description binding site for Poly-Saccharide residues NAG B 706 through BMA B 708 bound to ASN B 566 source : AC7 34) chain B residue 570 type ligand sequence A description binding site for Poly-Saccharide residues NAG B 706 through BMA B 708 bound to ASN B 566 source : AC7 35) chain B residue 571 type ligand sequence V description binding site for Poly-Saccharide residues NAG B 706 through BMA B 708 bound to ASN B 566 source : AC7 36) chain B residue 572 type ligand sequence R description binding site for Poly-Saccharide residues NAG B 706 through BMA B 708 bound to ASN B 566 source : AC7 37) chain A residue 191 type ACT_SITE ligand sequence G description {ECO:0000255}. source Swiss-Prot : SWS_FT_FI1 38) chain A residue 373 type ACT_SITE ligand sequence P description {ECO:0000255}. source Swiss-Prot : SWS_FT_FI1 39) chain A residue 223 type METAL ligand sequence I description Copper A. {ECO:0000250} source Swiss-Prot : SWS_FT_FI2 40) chain A residue 224 type METAL ligand sequence P description Copper A. {ECO:0000250} source Swiss-Prot : SWS_FT_FI2 41) chain A residue 294 type METAL ligand sequence Y description Copper A. {ECO:0000250} source Swiss-Prot : SWS_FT_FI2 42) chain A residue 373 type METAL ligand sequence P description Copper B. {ECO:0000250} source Swiss-Prot : SWS_FT_FI3 43) chain A residue 375 type METAL ligand sequence M description Copper B. {ECO:0000250} source Swiss-Prot : SWS_FT_FI3 44) chain A residue 448 type METAL ligand sequence R description Copper B. {ECO:0000250} source Swiss-Prot : SWS_FT_FI3 45) chain B residue 191 type ACT_SITE ligand sequence G description {ECO:0000255}. source Swiss-Prot : SWS_FT_FI5 46) chain B residue 373 type ACT_SITE ligand sequence P description {ECO:0000255}. source Swiss-Prot : SWS_FT_FI5 47) chain B residue 223 type METAL ligand sequence I description Copper A. {ECO:0000250} source Swiss-Prot : SWS_FT_FI6 48) chain B residue 224 type METAL ligand sequence P description Copper A. {ECO:0000250} source Swiss-Prot : SWS_FT_FI6 49) chain B residue 294 type METAL ligand sequence Y description Copper A. {ECO:0000250} source Swiss-Prot : SWS_FT_FI6 50) chain B residue 373 type METAL ligand sequence P description Copper B. {ECO:0000250} source Swiss-Prot : SWS_FT_FI7 51) chain B residue 375 type METAL ligand sequence M description Copper B. {ECO:0000250} source Swiss-Prot : SWS_FT_FI7 52) chain B residue 448 type METAL ligand sequence R description Copper B. {ECO:0000250} source Swiss-Prot : SWS_FT_FI7 53) chain A residue 47-48 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence LP description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_702 54) chain A residue 64-66 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence NVS description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_702 55) chain A residue 73 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence H description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_702 56) chain A residue 146 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence L description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_702 57) chain A residue 175 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence E description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_705 58) chain A residue 177 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence F description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_705 59) chain A residue 182 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence A description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_705 60) chain A residue 184 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence N description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_705 61) chain A residue 186 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence S description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_705 62) chain A residue 296 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence R description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_703 63) chain A residue 370 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence V description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_703 64) chain A residue 502 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence L description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_703 65) chain A residue 564 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence H description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_703 66) chain A residue 566 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence N description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_703 67) chain A residue 570-572 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence AVR description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_A_703 68) chain B residue 47 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence L description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_705 69) chain B residue 64-65 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence NV description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_705 70) chain B residue 73 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence H description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_705 71) chain B residue 146 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence L description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_705 72) chain B residue 219-222 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence PNIQ description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_701 73) chain B residue 344 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence N description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_701 74) chain B residue 370 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence V description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_706 75) chain B residue 502 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence L description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_706 76) chain B residue 564 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence H description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_706 77) chain B residue 566 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence N description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_706 78) chain B residue 569-572 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence SAVR description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_706 79) chain B residue 569-570 type binding ligand NAG: N-ACETYL-D-GLUCOSAMINE sequence SA description N-ACETYL-D-GLUCOSAMINE binding site source pdb_hetatom : NAG_4zel_B_707

Display surface Download Links