eF-site ID 4zc1-ABCDEFGHIJKL PDB Code 4zc1 Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Crystal Structure of type II Dehydroquinate dehydratase from Acinetobacter baumannii with a different crystal form at 2.52 A Resolution Classification LYASE Compound 3-dehydroquinate dehydratase Source Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (AROQ_ACIBT) Sequence A:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ B:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ C:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ D:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ E:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ F:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ G:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ H:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ I:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ J:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ K:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ L:  MSSTILVIHGPNLNLLGKREPEVYGHLTLDNINRQLIAQA EQASITLDTFQSNWEGAIVDRIHQAQTEGVKLIIINPAAL THTSVALRDALLGVAIPFIEVHLSNVHAREAFRHHSYLSD KAIGVICGLGAKGYSFALDYAIEKIQ Description Functional site 1) chain A residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 2) chain J residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 3) chain K residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 4) chain L residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 6) chain C residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 7) chain D residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 8) chain E residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 9) chain F residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 10) chain G residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 11) chain H residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 12) chain I residue 24 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 14) chain J residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 15) chain K residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 16) chain L residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 17) chain B residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 18) chain C residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 19) chain D residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 20) chain E residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 21) chain F residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 22) chain G residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 23) chain H residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 24) chain I residue 102 type ACT_SITE sequence H description Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 26) chain J residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 27) chain K residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 28) chain L residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 30) chain C residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 31) chain D residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 32) chain E residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 33) chain F residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 34) chain G residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 35) chain H residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 36) chain I residue 19 type SITE sequence R description Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI4 37) chain A residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 39) chain C residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 40) chain C residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 41) chain C residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 42) chain C residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 43) chain C residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 44) chain D residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 45) chain D residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 46) chain D residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 47) chain D residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 48) chain A residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 49) chain D residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 50) chain E residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 51) chain E residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 52) chain E residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 53) chain E residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 54) chain E residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 55) chain F residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 56) chain F residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 57) chain F residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 58) chain F residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 59) chain A residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 60) chain F residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 61) chain G residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 62) chain G residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 63) chain G residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 64) chain G residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 65) chain G residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 66) chain H residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 67) chain H residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 68) chain H residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 69) chain H residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 70) chain A residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 71) chain H residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 72) chain I residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 73) chain I residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 74) chain I residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 75) chain I residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 76) chain I residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 77) chain J residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 78) chain J residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 79) chain J residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 80) chain J residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 81) chain A residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 82) chain J residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 83) chain K residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 84) chain K residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 85) chain K residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 86) chain K residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 87) chain K residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 88) chain L residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 89) chain L residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 90) chain L residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 91) chain L residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 92) chain B residue 76 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 93) chain L residue 113 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 94) chain B residue 82 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 95) chain B residue 89 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 96) chain B residue 103 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00169 source Swiss-Prot : SWS_FT_FI3 97) chain A residue 8-25 type prosite sequence IHGPNLNLLGKREPEVYG description DEHYDROQUINASE_II Dehydroquinase class II signature. IHGPNLnlLGkREpevYG source prosite : PS01029

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