eF-site ID 4z2w-A PDB Code 4z2w Chain A click to enlarge Title Factor Inhibiting HIF in Complex with Fe, and Alpha-Ketoglutarate Classification OXIDOREDUCTASE Compound Hypoxia-inducible factor 1-alpha inhibitor Source Homo sapiens (Human) (HIF1N_HUMAN) Sequence A:  VASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQS DPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNG DFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEF VEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWN WINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFA QIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPD YERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGG ITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGE ALGNPQEVGPLLNTMIKGRYN Description Functional site 1) chain A residue 145 type sequence Y description binding site for residue AKG A 401 source : AC1 2) chain A residue 188 type sequence L description binding site for residue AKG A 401 source : AC1 3) chain A residue 196 type sequence T description binding site for residue AKG A 401 source : AC1 4) chain A residue 199 type sequence H description binding site for residue AKG A 401 source : AC1 5) chain A residue 201 type sequence D description binding site for residue AKG A 401 source : AC1 6) chain A residue 205 type sequence N description binding site for residue AKG A 401 source : AC1 7) chain A residue 207 type sequence F description binding site for residue AKG A 401 source : AC1 8) chain A residue 214 type sequence K description binding site for residue AKG A 401 source : AC1 9) chain A residue 279 type sequence H description binding site for residue AKG A 401 source : AC1 10) chain A residue 281 type sequence I description binding site for residue AKG A 401 source : AC1 11) chain A residue 294 type sequence N description binding site for residue AKG A 401 source : AC1 12) chain A residue 296 type sequence W description binding site for residue AKG A 401 source : AC1 13) chain A residue 102 type sequence Y description binding site for residue PEG A 402 source : AC2 14) chain A residue 199 type sequence H description binding site for residue PEG A 402 source : AC2 15) chain A residue 238 type sequence R description binding site for residue PEG A 402 source : AC2 16) chain A residue 199 type sequence H description binding site for residue FE A 403 source : AC3 17) chain A residue 201 type sequence D description binding site for residue FE A 403 source : AC3 18) chain A residue 279 type sequence H description binding site for residue FE A 403 source : AC3 19) chain A residue 311 type sequence K description binding site for residue SO4 A 404 source : AC4 20) chain A residue 312 type sequence A description binding site for residue SO4 A 404 source : AC4 21) chain A residue 107 type sequence K description binding site for residue SO4 A 405 source : AC5 22) chain A residue 320 type sequence R description binding site for residue SO4 A 405 source : AC5 23) chain A residue 324 type sequence K description binding site for residue SO4 A 405 source : AC5 24) chain A residue 138 type sequence R description binding site for residue SO4 A 406 source : AC6 25) chain A residue 140 type sequence G description binding site for residue SO4 A 406 source : AC6 26) chain A residue 141 type sequence E description binding site for residue SO4 A 406 source : AC6 27) chain A residue 142 type sequence E description binding site for residue SO4 A 406 source : AC6 28) chain A residue 17 type sequence R description binding site for residue SO4 A 407 source : AC7 29) chain A residue 44 type sequence R description binding site for residue SO4 A 407 source : AC7 30) chain A residue 65 type sequence T description binding site for residue SO4 A 407 source : AC7 31) chain A residue 224 type sequence F description binding site for residue SO4 A 408 source : AC8 32) chain A residue 225 type sequence E description binding site for residue SO4 A 408 source : AC8 33) chain A residue 199 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 34) chain A residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 35) chain A residue 279 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 36) chain A residue 340 type SITE sequence L description Important for dimer formation source Swiss-Prot : SWS_FT_FI4 37) chain A residue 145 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 196 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 205 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 214 type BINDING sequence K description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 294 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 152 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 181 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 238 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 300 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2

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