eF-site ID 4yzf-A
PDB Code 4yzf
Chain A

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Title Crystal structure of the anion exchanger domain of human erythrocyte Band 3
Classification IMMUNE SYSTEM
Compound Band 3 anion transport protein
Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence A:  GLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPA
ITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLL
VVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILL
VVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKL
IKIFQDHPLQKTYLPNTALLSLVLMAGTFFFAMMLRKFKN
SSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLS
VPDGFKVVIHPLGLRSEFPIWMMFASALPALLVFILIFLE
SQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGM
PWLSATTVRSVTHANALTVMIQEVKEQRISGLLVAVLVGL
SILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLL
FKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKS
TPASLALPFVLILTVPLRRVLLPLIFRNVELQCLD
Description (1)  Outward facing structure of human anion exchanger 1 (Band 3) in co-crystallised with FAB antibody fragments. , FAB fragment of Immunoglobulin (IgG) molecule


Functional site

1) chain A
residue 419
type
sequence P
description binding site for residue 4KU A 1000
source : AC1

2) chain A
residue 467
type
sequence P
description binding site for residue 4KU A 1000
source : AC1

3) chain A
residue 532
type
sequence F
description binding site for residue 4KU A 1000
source : AC1

4) chain A
residue 535
type
sequence E
description binding site for residue 4KU A 1000
source : AC1

5) chain A
residue 539
type
sequence K
description binding site for residue 4KU A 1000
source : AC1

6) chain A
residue 681
type
sequence E
description binding site for residue 4KU A 1000
source : AC1

7) chain A
residue 851
type
sequence K
description binding site for residue 4KU A 1000
source : AC1

8) chain A
residue 843
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000269|PubMed:1885574
source Swiss-Prot : SWS_FT_FI24

9) chain A
residue 404-427
type TRANSMEM
sequence QVLAAVIFIYFAALSPAITFGGLL
description Helical; Name=1 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI2

10) chain A
residue 428-435
type TOPO_DOM
sequence GEKTRNQM
description Extracellular => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI3

11) chain A
residue 477-485
type TOPO_DOM
sequence SFCETNGLE
description Extracellular => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI3

12) chain A
residue 542-570
type TOPO_DOM
sequence KIFQDHPLQKTYLPNT
description Extracellular => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI3

13) chain A
residue 624-663
type TOPO_DOM
sequence IQDTYTQKLSVPDGFKVVIHPLGLRSEFPIWM
description Extracellular => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI3

14) chain A
residue 436-456
type TRANSMEM
sequence GVSELLISTAVQGILFALLGA
description Helical; Name=2 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI4

15) chain A
residue 460-476
type TRANSMEM
sequence LVVGFSGPLLVFEEAFF
description Discontinuously helical; Name=3 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI5

16) chain A
residue 486-506
type TRANSMEM
sequence YIVGRVWIGFWLILLVVLVVA
description Helical; Name=4 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI6

17) chain A
residue 519-541
type TRANSMEM
sequence YTQEIFSFLISLIFIYETFSKLI
description Helical; Name=5 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI7

18) chain A
residue 571-591
type TRANSMEM
sequence ALLSLVLMAGTFFFAMMLRKF
description Helical; Name=6 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI8

19) chain A
residue 603-623
type TRANSMEM
sequence RVIGDFGVPISILIMVLVDFF
description Helical; Name=7 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI9

20) chain A
residue 457-459
type TOPO_DOM
sequence QPL
description Cytoplasmic => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 507-518
type TOPO_DOM
sequence FEGSFLVRFISR
description Cytoplasmic => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI1

22) chain A
residue 592-602
type TOPO_DOM
sequence KNSSYFPGKLR
description Cytoplasmic => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 685-700
type TOPO_DOM
sequence TTLIVSKPERKMVKGS
description Cytoplasmic => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI1

24) chain A
residue 738-760
type TOPO_DOM
sequence LTVMIQEVKEQR
description Cytoplasmic => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI1

25) chain A
residue 801-838
type TOPO_DOM
sequence SGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTG
description Cytoplasmic => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI1

26) chain A
residue 664-684
type TRANSMEM
sequence MFASALPALLVFILIFLESQI
description Helical; Name=8 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI10

27) chain A
residue 701-719
type TRANSMEM
sequence GFHLDLLLVVGMGGVAALF
description Helical; Name=9 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI11

28) chain A
residue 720-737
type TRANSMEM
sequence GMPWLSATTVRSVTHANA
description Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI12

29) chain A
residue 761-781
type TRANSMEM
sequence ISGLLVAVLVGLSILMEPILS
description Helical; Name=11 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI13

30) chain A
residue 782-800
type TRANSMEM
sequence RIPLAVLFGIFLYMGVTSL
description Helical; Name=12 => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI14

31) chain A
residue 590
type SITE
sequence K
description Important for anion transport
source Swiss-Prot : SWS_FT_FI16

32) chain A
residue 681
type SITE
sequence E
description Important for anion-proton cotransport
source Swiss-Prot : SWS_FT_FI17

33) chain A
residue 839-869
type INTRAMEM
sequence IQIICLAVLWVVKSTPASLALPFVLILTVPL
description Discontinuously helical => ECO:0000269|PubMed:26542571
source Swiss-Prot : SWS_FT_FI15

34) chain A
residue 526-540
type prosite
sequence FLISLIFIYETFSKL
description ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL
source prosite : PS00220


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