eF-site ID 4yzf-B PDB Code 4yzf Chain B click to enlarge Title Crystal structure of the anion exchanger domain of human erythrocyte Band 3 Classification IMMUNE SYSTEM Compound Band 3 anion transport protein Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence B:  GLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPA ITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLL VVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILL VVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKL IKIFQDHPLQKTYLPNTALLSLVLMAGTFFFAMMLRKFKN SSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLS VPDGFKVVIHPLGLRSEFPIWMMFASALPALLVFILIFLE SQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGM PWLSATTVRSVTHANALTVMIQEVKEQRISGLLVAVLVGL SILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLL FKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKS TPASLALPFVLILTVPLRRVLLPLIFRNVELQCLD Description (1)  Outward facing structure of human anion exchanger 1 (Band 3) in co-crystallised with FAB antibody fragments. , FAB fragment of Immunoglobulin (IgG) molecule Functional site 1) chain B residue 422 type sequence T description binding site for residue 4KU B 1000 source : AC2 2) chain B residue 467 type sequence P description binding site for residue 4KU B 1000 source : AC2 3) chain B residue 532 type sequence F description binding site for residue 4KU B 1000 source : AC2 4) chain B residue 535 type sequence E description binding site for residue 4KU B 1000 source : AC2 5) chain B residue 539 type sequence K description binding site for residue 4KU B 1000 source : AC2 6) chain B residue 792 type sequence F description binding site for residue 4KU B 1000 source : AC2 7) chain B residue 851 type sequence K description binding site for residue 4KU B 1000 source : AC2 8) chain B residue 843 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:1885574 source Swiss-Prot : SWS_FT_FI24 9) chain B residue 404-427 type TRANSMEM sequence QVLAAVIFIYFAALSPAITFGGLL description Helical; Name=1 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 428-435 type TOPO_DOM sequence GEKTRNQM description Extracellular => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 477-485 type TOPO_DOM sequence SFCETNGLE description Extracellular => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 542-570 type TOPO_DOM sequence KIFQDHPLQKTYLPNT description Extracellular => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 624-663 type TOPO_DOM sequence IQDTYTQKLSVPDGFKVVIHPLGLRSEFPIWM description Extracellular => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 436-456 type TRANSMEM sequence GVSELLISTAVQGILFALLGA description Helical; Name=2 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI4 15) chain B residue 460-476 type TRANSMEM sequence LVVGFSGPLLVFEEAFF description Discontinuously helical; Name=3 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI5 16) chain B residue 486-506 type TRANSMEM sequence YIVGRVWIGFWLILLVVLVVA description Helical; Name=4 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI6 17) chain B residue 519-541 type TRANSMEM sequence YTQEIFSFLISLIFIYETFSKLI description Helical; Name=5 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI7 18) chain B residue 571-591 type TRANSMEM sequence ALLSLVLMAGTFFFAMMLRKF description Helical; Name=6 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI8 19) chain B residue 603-623 type TRANSMEM sequence RVIGDFGVPISILIMVLVDFF description Helical; Name=7 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI9 20) chain B residue 457-459 type TOPO_DOM sequence QPL description Cytoplasmic => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 507-518 type TOPO_DOM sequence FEGSFLVRFISR description Cytoplasmic => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 592-602 type TOPO_DOM sequence KNSSYFPGKLR description Cytoplasmic => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 685-700 type TOPO_DOM sequence TTLIVSKPERKMVKGS description Cytoplasmic => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 738-760 type TOPO_DOM sequence LTVMIQEVKEQR description Cytoplasmic => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 801-838 type TOPO_DOM sequence SGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTG description Cytoplasmic => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 664-684 type TRANSMEM sequence MFASALPALLVFILIFLESQI description Helical; Name=8 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI10 27) chain B residue 701-719 type TRANSMEM sequence GFHLDLLLVVGMGGVAALF description Helical; Name=9 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI11 28) chain B residue 720-737 type TRANSMEM sequence GMPWLSATTVRSVTHANA description Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI12 29) chain B residue 761-781 type TRANSMEM sequence ISGLLVAVLVGLSILMEPILS description Helical; Name=11 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI13 30) chain B residue 782-800 type TRANSMEM sequence RIPLAVLFGIFLYMGVTSL description Helical; Name=12 => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI14 31) chain B residue 590 type SITE sequence K description Important for anion transport source Swiss-Prot : SWS_FT_FI16 32) chain B residue 681 type SITE sequence E description Important for anion-proton cotransport source Swiss-Prot : SWS_FT_FI17 33) chain B residue 839-869 type INTRAMEM sequence IQIICLAVLWVVKSTPASLALPFVLILTVPL description Discontinuously helical => ECO:0000269|PubMed:26542571 source Swiss-Prot : SWS_FT_FI15

Display surface Download Links