eF-site ID 4yxr-A PDB Code 4yxr Chain A click to enlarge Title CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH inhibitor. Classification TRANSFERASE Compound cAMP-dependent protein kinase catalytic subunit alpha Source Bos taurus (Bovine) (IPKA_BOVIN) Sequence A:  VKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSF GRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRI LQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRR IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI DQQGYIQVTDFGFAKRVKGRTWXLCGTPEYLAPEIILSKG YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKDGVNDIKNH KWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE IRVXINEKCGKEFSEF Description (1)  C-AMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37) Functional site 1) chain A residue 70 type sequence A description binding site for residue 0RW A 401 source : AC1 2) chain A residue 121 type sequence E description binding site for residue 0RW A 401 source : AC1 3) chain A residue 122 type sequence Y description binding site for residue 0RW A 401 source : AC1 4) chain A residue 123 type sequence V description binding site for residue 0RW A 401 source : AC1 5) chain A residue 173 type sequence L description binding site for residue 0RW A 401 source : AC1 6) chain A residue 183 type sequence T description binding site for residue 0RW A 401 source : AC1 7) chain A residue 327 type sequence F description binding site for residue 0RW A 401 source : AC1 8) chain A residue 166 type catalytic sequence D description 757 source MCSA : MCSA1 9) chain A residue 168 type catalytic sequence K description 757 source MCSA : MCSA1 10) chain A residue 171 type catalytic sequence N description 757 source MCSA : MCSA1 11) chain A residue 184 type catalytic sequence D description 757 source MCSA : MCSA1 12) chain A residue 201 type catalytic sequence T description 757 source MCSA : MCSA1 13) chain A residue 338 type MOD_RES sequence X description Phosphoserine => ECO:0000269|PubMed:6262777 source Swiss-Prot : SWS_FT_FI10 14) chain A residue 48 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P17612 source Swiss-Prot : SWS_FT_FI6 15) chain A residue 195 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P17612 source Swiss-Prot : SWS_FT_FI6 16) chain A residue 139 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P05132 source Swiss-Prot : SWS_FT_FI7 17) chain A residue 197 type MOD_RES sequence X description Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:6262777 source Swiss-Prot : SWS_FT_FI8 18) chain A residue 330 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P05132 source Swiss-Prot : SWS_FT_FI9 19) chain A residue 49 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 20) chain A residue 72 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 21) chain A residue 121 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 168 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 49-72 type prosite sequence LGTGSFGRVMLVKHMETGNHYAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhmetgnh..........YAMK source prosite : PS00107 24) chain A residue 162-174 type prosite sequence LIYRDLKPENLLI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI source prosite : PS00108

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