eF-site ID 4yp3-A
PDB Code 4yp3
Chain A

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Title Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion
Classification Transferase/DNA
Compound DNA polymerase eta
Source (4YP3)
Sequence A:  GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVV
AYKSWKGGGIIAVSYEARAFGVTASMWADDAKKLCPDLLL
AQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEA
YVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQTVQKE
GMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAI
ERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVP
QLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTES
QLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKN
FPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVAT
QLVVSIRVQGSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFSAS
Description


Functional site

1) chain A
residue 13
type
sequence D
description binding site for residue DCP A 501
source : AC1

2) chain A
residue 14
type
sequence M
description binding site for residue DCP A 501
source : AC1

3) chain A
residue 15
type
sequence D
description binding site for residue DCP A 501
source : AC1

4) chain A
residue 16
type
sequence C
description binding site for residue DCP A 501
source : AC1

5) chain A
residue 17
type
sequence F
description binding site for residue DCP A 501
source : AC1

6) chain A
residue 18
type
sequence F
description binding site for residue DCP A 501
source : AC1

7) chain A
residue 48
type
sequence I
description binding site for residue DCP A 501
source : AC1

8) chain A
residue 49
type
sequence A
description binding site for residue DCP A 501
source : AC1

9) chain A
residue 52
type
sequence Y
description binding site for residue DCP A 501
source : AC1

10) chain A
residue 55
type
sequence R
description binding site for residue DCP A 501
source : AC1

11) chain A
residue 115
type
sequence D
description binding site for residue DCP A 501
source : AC1

12) chain A
residue 231
type
sequence K
description binding site for residue DCP A 501
source : AC1

13) chain A
residue 13
type
sequence D
description binding site for residue CA A 502
source : AC2

14) chain A
residue 14
type
sequence M
description binding site for residue CA A 502
source : AC2

15) chain A
residue 115
type
sequence D
description binding site for residue CA A 502
source : AC2

16) chain A
residue 13
type
sequence D
description binding site for residue CA A 503
source : AC3

17) chain A
residue 115
type
sequence D
description binding site for residue CA A 503
source : AC3

18) chain A
residue 116
type
sequence E
description binding site for residue CA A 503
source : AC3

19) chain A
residue 24
type
sequence R
description binding site for residue GOL A 504
source : AC4

20) chain A
residue 244
type
sequence P
description binding site for residue GOL A 504
source : AC4

21) chain A
residue 247
type
sequence F
description binding site for residue GOL A 504
source : AC4

22) chain A
residue 248
type
sequence S
description binding site for residue GOL A 504
source : AC4

23) chain A
residue 276
type
sequence G
description binding site for residue GOL A 504
source : AC4

24) chain A
residue 277
type
sequence E
description binding site for residue GOL A 504
source : AC4

25) chain A
residue 111
type
sequence R
description binding site for residue GOL A 505
source : AC5

26) chain A
residue 112
type
sequence A
description binding site for residue GOL A 505
source : AC5

27) chain A
residue 113
type
sequence S
description binding site for residue GOL A 505
source : AC5

28) chain A
residue 114
type
sequence I
description binding site for residue GOL A 505
source : AC5

29) chain A
residue 13
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 14
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO
source Swiss-Prot : SWS_FT_FI1

31) chain A
residue 115
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO
source Swiss-Prot : SWS_FT_FI1

32) chain A
residue 116
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO
source Swiss-Prot : SWS_FT_FI1

33) chain A
residue 61
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:27284197
source Swiss-Prot : SWS_FT_FI2


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